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Titolo:
RARITY OF DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN CHINESE PATIENTS WITH PARKINSONS-DISEASE
Autore:
PANG CP; ZHANG J; WOO J; CHAN D; LAW LK; TONG SF; KWOK T; KAY R;
Indirizzi:
CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT CHEM PATHOL SHATIN HONGKONG CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT MED SHATIN HONG KONG UNITED CHRISTIAN HOSP,DEPT MED HONG KONG HONG KONG
Titolo Testata:
Movement disorders
fascicolo: 3, volume: 13, anno: 1998,
pagine: 529 - 532
SICI:
0885-3185(1998)13:3<529:RODHGP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYP2D6 GENE; POOR METABOLIZERS; ALLELE; LOCUS; IDENTIFICATION; ASSOCIATION; POPULATION; DEFECT;
Keywords:
CHINESE; PARKINSONS DISEASE; CYP2D6 POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Pang et al., "RARITY OF DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN CHINESE PATIENTS WITH PARKINSONS-DISEASE", Movement disorders, 13(3), 1998, pp. 529-532

Abstract

Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease (PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control subjects by polymerase chain reaction and restriction analysis. The G to A substitution at position 1934 in the junction of intron 3/exon 4 was detected in one sporadic PD patient and two control subjects, all of whom were heterozygous, The single base deletion at position 2637 in exon 5 was not detected in any of,:he study subjects. Such rarity of CYP2D6 polymorphism indicates PD in the Chinese population is associated with some other gene defects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:19:16