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Titolo:
VIRUS INACTIVATION IN SUPEROXIDE-DISMUTASE PREPARATIONS BY ULTRAVIOLET-LIGHT IRRADIATION
Autore:
HIRAYAMA J; ABE H; IKEBUCHI K; HORIUCHI M; SHINAGAWA M; KAMO N; SEKIGUCHI S;
Indirizzi:
HOKKAIDO RED CROSS,CTR BLOOD,NISHI KU,YAMANOTE 2-2 SAPPORO HOKKAIDO 063 JAPAN OBIHIRO UNIV AGR & VET MED,DEPT VET PUBL HLTH OBIHIRO HOKKAIDO 080 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT BIOPHYS CHEM SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 6, volume: 21, anno: 1998,
pagine: 621 - 623
SICI:
0918-6158(1998)21:6<621:VIISPB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARVOVIRUS; PROTEINS;
Keywords:
VIRAL INACTIVATION; SUPEROXIDE DISMUTASE; ULTRAVIOLET LIGHT C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Hirayama et al., "VIRUS INACTIVATION IN SUPEROXIDE-DISMUTASE PREPARATIONS BY ULTRAVIOLET-LIGHT IRRADIATION", Biological & pharmaceutical bulletin, 21(6), 1998, pp. 621-623

Abstract

Viral inactivation in superoxide dismutase (SOD) derived from human red cells was carried out by ultraviolet light C (UVC) irradiation. With 400 J/m(2) UVC irradiation, the titer of canine parvovirus (CPV, a nonenveloped virus), M13 bacteriophage (M13, a nonenveloped phage) and vesicular stomatitis virus (VSV, an enveloped virus), which were spiked into SOD solution, were reduced by >4.6 log(10) (detection limit), 7.0 log(10) and 6.2 log(10),( )respectively The SOD activity was maintained and the band pattern of SOD on an electrophoresis gel was not changed even by 1000 J/m(2) UVC irradiation. These results indicate that UVC irradiation is a promising method for the inactivation of both enveloped and nonenveloped viruses in SOD preparations while maintaining its activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:26:38