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Titolo:
OXIDATIVE DAMAGE TO PROTEINS, LIPIDS, AND DNA IN CORTICAL BRAIN-REGIONS FROM PATIENTS WITH DEMENTIA WITH LEWY BODIES
Autore:
LYRAS L; PERRY RH; PERRY EK; INCE PG; JENNER A; JENNER P; HALLIWELL B;
Indirizzi:
UNIV LONDON KINGS COLL,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR,MANRESA RD LONDON SW3 6LX ENGLAND UNIV LONDON KINGS COLL,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR LONDON SW3 6LX ENGLAND NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Journal of neurochemistry
fascicolo: 1, volume: 71, anno: 1998,
pagine: 302 - 312
SICI:
0022-3042(1998)71:1<302:ODTPLA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; PARKINSONIAN SUBSTANTIA-NIGRA; SUPEROXIDE-DISMUTASE ACTIVITY; ALZHEIMERS-DISEASE; SELECTIVE INCREASE; SENILE DEMENTIA; BODY DISEASE; L-DOPA; PEROXIDATION; ANTIOXIDANT;
Keywords:
DEMENTIA WITH LEWY BODIES; ALZHEIMERS DISEASE; OXIDIZED DNA BASES; LIPID PEROXIDATION; PROTEIN CARBONYLS; OXIDATIVE STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
L. Lyras et al., "OXIDATIVE DAMAGE TO PROTEINS, LIPIDS, AND DNA IN CORTICAL BRAIN-REGIONS FROM PATIENTS WITH DEMENTIA WITH LEWY BODIES", Journal of neurochemistry, 71(1), 1998, pp. 302-312

Abstract

Dementia with Lewy bodies (DLB) forms the second most common pathological subgroup of dementia after Alzheimer's disease. The present studycompares the levels of oxidative damage to proteins, lipids, and DNA bases in cortical brain areas from patients with DLB with levels in matched control tissues. Overall, there was a trend for protein carbonyllevels to be increased in all areas, but a significant difference wasfound only in the parietal and temporal lobes. No differences were observed in the levels of lipid peroxidation. Measurement of products ofdamage to DNA bases showed increased levels of thymine glycol, 8-hydroxyguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, 5-hydroxycytosine, 5-hydroxyuracil, 5-hydroxymethyluracil, and xanthine. Xanthine levels were increased in the DLB group in the parietal, occipital, and temporal robes, indicating that peroxynitrite or other deaminating species may be involved. The finding of increased protein carbonyls and increased DNA base products in cortical regions from DLB patients indicates that oxidative stress may play a role in DLB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:26:17