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Titolo:
SIMULTANEOUS DETERMINATION OF AN ACTIVE METABOLITE AND OPEN-RING METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND PHARMACOKINETIC STUDIES OF A PENEM ANTIBIOTIC, FCE22891, IN DOGS
Autore:
MATSUOKA M; IMADO N; MAKI T; BANNO K; SATO T;
Indirizzi:
TANABE SEIYAKU CO LTD,ANALYT RES LAB,YODOGAWA KU,16-89 KASHIMA 3 CHOME OSAKA JAPAN
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 2, volume: 17, anno: 1998,
pagine: 255 - 266
SICI:
0731-7085(1998)17:2<255:SDOAAM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL DIPEPTIDASE; HUMAN PLASMA; PRO-DRUG; FCE-22101; PIVALOYLCARNITINE; PIVAMPICILLIN; EXCRETION; CARNITINE; ANIMALS; ESTERS;
Keywords:
PENEM ANTIBIOTIC; OPEN-RING METABOLITES; PHARMACOKINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Matsuoka et al., "SIMULTANEOUS DETERMINATION OF AN ACTIVE METABOLITE AND OPEN-RING METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND PHARMACOKINETIC STUDIES OF A PENEM ANTIBIOTIC, FCE22891, IN DOGS", Journal of pharmaceutical and biomedical analysis, 17(2), 1998, pp. 255-266

Abstract

A sensitive high performance liquid chromatographic method for the simultaneous determination of an active metabolite (FCE22101) and open-ring metabolites (P1, P2) of a penem antibiotic, FCE22891. in dog plasma was developed. Plasma samples were pretreated only by ultrafiltration for the determination oi.;he metabolites. The filtrates were directly analyzed by a reversed-phase high-performance liquid chromatographicsystem using a two-sided bracketing injection technique. The quantitation limits of FCE22101, Pt and P2 were 0.03, 0.1 and 0.15 mu g ml(-1), respectively. Analysis of the spiked plasma samples demonstrated thegood accuracy and precision of the method. The proposed method was applied to the pharmacokinetic studies of an active metabolite and open-ring metabolites after oral administration of a penem antibiotic, FCE22891, in dogs. In addition, the plasma levels of unchanged FCE22891 and the possible changes of formaldehyde and acyl-L-carnitine levels in plasma, which will be generated from the ester group of FCE22891, werealso investigated. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:54:16