Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN ELDERLY PATIENTS CLINICALLY RECOVERED FROM EARLY-ONSET AND LATE-ONSET DEPRESSION
Autore:
DAHABRA S; ASHTON CH; BAHRAINIAN M; BRITTON PG; FERRIER IN; MCALLISTER VA; MARSH VR; MOORE PB;
Indirizzi:
ROYAL VICTORIA INFIRM,DEPT PSYCHIAT NEWCASTLE TYNE NE1 4LP TYNE & WEAR ENGLAND ROYAL VICTORIA INFIRM,DEPT PSYCHIAT NEWCASTLE TYNE NE1 4LP TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEURORADIOL NEWCASTLE TYNE TYNE & WEAR ENGLAND S TYNESIDE DIST HOSP S SHIELDS ENGLAND
Titolo Testata:
Biological psychiatry
fascicolo: 1, volume: 44, anno: 1998,
pagine: 34 - 46
SICI:
0006-3223(1998)44:1<34:SAFAIE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; CEREBRAL BLOOD-FLOW; ALZHEIMER-TYPE DEMENTIA; MILD SENILE DEMENTIA; MAJOR DEPRESSION; GERIATRIC DEPRESSION; COMPUTED-TOMOGRAPHY; AFFECTIVE-DISORDER; EVOKED-POTENTIALS; BRAIN POTENTIALS;
Keywords:
MAGNETIC RESONANCE IMAGING; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; COGNITIVE PERFORMANCE; ELDERLY DEPRESSION; EARLY-ONSET DEPRESSION; LATE-ONSET DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
99
Recensione:
Indirizzi per estratti:
Citazione:
S. Dahabra et al., "STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN ELDERLY PATIENTS CLINICALLY RECOVERED FROM EARLY-ONSET AND LATE-ONSET DEPRESSION", Biological psychiatry, 44(1), 1998, pp. 34-46

Abstract

Background: Structural and functional brain changes have been described in elderly patients with unipolar affective disorder. Changes appear to be more marked in patients with late-onset depression, but the reversibility of such changes after clinical recovery is not known. Methods: Magnetic resonance imaging, electroencephalography (EEG), and cognitive tests were performed in 23 elderly patients (mean age 66.5 years) clinically recovered from major depression. Twelve had late-onset depression (first episode over 55 years of age); 11 had early onset (first episode before 50 years), EEG and cognitive testing were also performed on 15 control subjects. Results: Patients with late-onset depression had larger third and lateral ventricles, increased ventricular-brain ratio, and greater frequency and severity of subcortical white matter lesions than those with early onset. There was no difference between early- and late-onset patients in EEG and cognitive measures, but compared with controls patients showed significant changes in EEG evoked potentials and increased slow-wave activity slowed reaction times, and global impairments in cognitive function. Conclusions: These results suggest that structural changes are greater in patients with late-onset depression, and that EEG and cognitive impairments persist after recovery regardless of age of onset of depression, and are independent of structural changes. Biol Psychiatry 1998;44:34-46 (C) 1998 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:14:08