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Titolo:
MILD GENTAMICIN-NEPHROTOXICITY REDUCES THE PROGRESSION OF CHRONIC ADRIAMYCIN NEPHROSIS
Autore:
RANGAN GK; WANG YP; TAY YC; CHEN LG; HARRIS DCH;
Indirizzi:
UNIV SYDNEY,WESTMEAD HOSP,DEPT RENAL MED WESTMEAD NSW 2145 AUSTRALIA
Titolo Testata:
Nephrology
fascicolo: 1-2, volume: 4, anno: 1998,
pagine: 57 - 64
SICI:
1320-5358(1998)4:1-2<57:MGRTPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-RENAL-FAILURE; CATHEPSIN-B; RAT-KIDNEY; FERRIC NITRILOTRIACETATE; TUBULAR-NECROSIS; PROTEINURIA; SEGMENTS; AMINOGLYCOSIDES; EXPRESSION; INDUCTION;
Keywords:
DOXORUBICIN; FERRIC NITRILOTRIACETATE; GENTAMICIN; GLOMERULOSCLEROSIS; PROTEINURIA; TUBULOINTERSTITIAL FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
G.K. Rangan et al., "MILD GENTAMICIN-NEPHROTOXICITY REDUCES THE PROGRESSION OF CHRONIC ADRIAMYCIN NEPHROSIS", Nephrology, 4(1-2), 1998, pp. 57-64

Abstract

The effect of mild acute tubular injury on the progression of tubulointerstitial fibrosis was studied in pair-fed uninephrectomized male Wistar rats with established adriamycin nephrosis (n=34). Rats were stratified into three groups according to endogenous creatinine clearance (CrCl), proteinuria (Upr) and body weight (BW): (i) group 1 (Fe, n=12)received a single intraperitoneal injection of ferric nitrilotriacetate (5 mg Fe/kg BW); (ii) group 2 (G, n = 10) three daily subcutaneous injections of gentamicin (60 mg/kg BW) and; (iii) group 3 (C, n=12) saline injections. Serial CrCl (day 2, day 5, weeks 2, 4, 6 and 8) and renal histology (week 8) were examined following administration of nephrotoxin. CrCl was reduced on d2 (Fe: 0.78 +/- 0.23 mL/min; mean +/- SD) and day 5 (G: 0.9 +/- 0.36 mL/min) as compared with C (1.22 +/- 0.12mL/min; P<0.05). There was no change in the serum creatinine and functional recovery occurred by d5 (Fe) and week 2 (G). Upr decreased transiently in G at week 2 (G: 482 +/- 208 mg/day vs C: 716 +/- 233; P = 0.05) despite similar food intake, baseline Upr and CrCl. At week 8, CrCl in Fe (0.84 +/- 0.40 mL/ min) was similar to C (0.84 +/- 0.58 mL/min), whereas in G it remained stable (1.27 +/- 0.39 mL/min; P<0.05). Bymorphometric analysis, mean relative interstitial volume (RIV) and glomerulosclerosis (GS) in Fe (RIV: 28.5 +/- 13.4%; GS: 10.3 +/- 12.3%) was no different to C (RIV: 24.5 +/- 12.5%; GS: 20.9 +/- 20.0%), whereas both parameters were reduced in G (RIV: 14.1 +/- 8.1%; GS: 4.0 +/- 4.8%; P<0.05). Mild gentamicin nephrotoxicity therefore reduced the progression of adriamycin nephrosis. The mechanism of this finding is unclear, but it may relate to altered glomerular and tubular cell handling of protein.

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Documento generato il 03/06/20 alle ore 09:47:25