Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FAILURE OF P-STRAIN MICE TO RESPOND TO VACCINATION AGAINST SCHISTOSOMIASIS CORRELATES WITH IMPAIRED PRODUCTION OF IL-12 AND UP-REGULATION OF TH2 CYTOKINES THAT INHIBIT MACROPHAGE ACTIVATION
Autore:
OSWALD IP; CASPAR P; WYNN TA; SCHARTONKERSTEN T; WILLIAMS ME; HIENY S; SHER A; JAMES SL;
Indirizzi:
INRA,LAB PHARMACOL TOXICOL,180 CHEMIN TOURNEFEUILLE,BP3 F-31931 TOULOUSE 9 FRANCE NIAID,PARASIT DIS LAB,NIH BETHESDA MD 20892
Titolo Testata:
European Journal of Immunology
fascicolo: 6, volume: 28, anno: 1998,
pagine: 1762 - 1772
SICI:
0014-2980(1998)28:6<1762:FOPMTR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-LIVING VACCINE; GROWTH-FACTOR-BETA; PROTECTIVE IMMUNITY; INTERFERON-GAMMA; ATTENUATED CERCARIAE; MONOCLONAL-ANTIBODY; INDUCED RESISTANCE; NITRIC-OXIDE; MANSONI; CELLS;
Keywords:
MONOCYTE/MACROPHAGE; SCHISTOSOME; VACCINATION; CYTOKINE; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
I.P. Oswald et al., "FAILURE OF P-STRAIN MICE TO RESPOND TO VACCINATION AGAINST SCHISTOSOMIASIS CORRELATES WITH IMPAIRED PRODUCTION OF IL-12 AND UP-REGULATION OF TH2 CYTOKINES THAT INHIBIT MACROPHAGE ACTIVATION", European Journal of Immunology, 28(6), 1998, pp. 1762-1772

Abstract

In contrast to most inbred strains, P mice fail to develop significant resistance to Schistosoma mansoni infection as a result of vaccination with either radiation-attenuated cercariae or schistosome antigens plus Bacillus Calmette Guerin, and this failure correlates with defects in macrophage larvicidal activity. Supernatant fluids from antigen-treated in vitro cultures of splenocytes from vaccinated P mice demonstrate less macrophage stimulatory activity than do supernatants from cells of vaccine-responsive strains such as C57BL/6. This is not due either to diminished production of the macrophage-activating cytokine IFN-gamma by P mice, or to a lesser responsiveness of macrophages from P mice to activation by IFN gamma. Rather, P splenocytes produce two-to threefold higher amounts of IL-4 and IL-10, cytokines which down-regulate the cytotoxic potential of IFN gamma-treated macrophages. Thus, the macrophage-activating potential of cytokine preparations from vaccinated P mice can be completely recovered by in vitro treatment with antibodies to IL-4 or IL-10. Moreover, lower levels of IL-12, a cytokine involved in promoting development of Th1 responses, are produced by splenocytes from P mice as compared to C57BL/6 counterparts. These studies indicate that a genetic predisposition toward an impaired production of IL-12 and an increased production of down-regulatory Th2 cytokines correlate with low response to vaccination against S. mansoni.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:33:12