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Titolo:
GRANULOMATOUS HYPOPHYSITIS CAUSED BY A RUPTURED INTRASELLAR RATHKES CLEFT CYST - REPORT OF A CASE AND REVIEW OF THE LITERATURE
Autore:
RONCAROLI F; BACCI A; FRANK G; CALBUCCI F;
Indirizzi:
UNIV BOLOGNA,OSPED BELLARIA,SERV ANAT ISTOL & CITOL PATOL,VIA ALTURA 3 I-40139 BOLOGNA ITALY UNIV BOLOGNA,DEPT ONCOL BOLOGNA ITALY UNIV BOLOGNA,SECT ANAT & CYTOPATHOL BOLOGNA ITALY BELLARIA HOSP,DIV NEURORADIOL BOLOGNA ITALY BELLARIA HOSP,DIV NEUROSURG BOLOGNA ITALY
Titolo Testata:
Neurosurgery
fascicolo: 1, volume: 43, anno: 1998,
pagine: 146 - 149
SICI:
0148-396X(1998)43:1<146:GHCBAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY GRANULOMA; HYPOPITUITARISM; DIAGNOSIS;
Keywords:
GRANULOMATOUS HYPOPHYSITIS; RATHKES CLEFT CYST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F. Roncaroli et al., "GRANULOMATOUS HYPOPHYSITIS CAUSED BY A RUPTURED INTRASELLAR RATHKES CLEFT CYST - REPORT OF A CASE AND REVIEW OF THE LITERATURE", Neurosurgery, 43(1), 1998, pp. 146-149

Abstract

OBJECTIVE AND IMPORTANCE: Ruptured Rathke's cleft cyst is a rare cause of giant cell granulomatous hypophysitis. Chronic inflammatory reaction is caused by extravased cyst content into the adjacent gland. We provide a demonstration that mucins produced by cells lining: the cyst wall caused the granulomatous giant cell reaction. CLINICAL PRESENTATION: A 37-year-old nonpregnant woman presented with a 3-year-history ofheadache and amenorrhea. She had experienced normal sexual maturation, and her medical history was unremarkable. Radiologically, the lesionappeared as an intrasellar mass with a cystic component indistinguishable from a pituitary adenoma with cystic degeneration. TECHNIQUE: Thepatient underwent a transsphenoidal approach. Because no demarcation between normal and affected tissue was evident at surgery, the lesion and residual pituitary were radically removed. Tissue was studied using routine hematoxylin and eosin and histochemical stainings for mucinsand immunocytochemical techniques. CONCLUSION: This study demonstrates that mucins that had spilled out from the cyst caused the granulomatous reaction. Using computed tomography, magnetic resonance imaging, and gross inspection, distinction between granulomatous hypophysitis and pituitary adenoma was virtually impossible. Nevertheless, a granulomatous reaction of the pituitary gland should be suspected in a case ofa sellar mass having a cystic area. In such cases, intraoperatory diagnosis on frozen sections is mandatory because adoption of a conservative treatment allows preservation of the gland.

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Documento generato il 05/12/20 alle ore 01:17:37