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Titolo:
DIFFERENTIAL INVOLVEMENT OF A FAS-CPP32-LIKE PROTEASE PATHWAY IN APOPTOSIS OF TCR CD9-COSTIMULATED, NAIVE T-CELLS AND TCR-RESTIMULATED, ACTIVATED T-CELLS/
Autore:
PARK CS; YASHIRO Y; TAI XG; TOYOOKA K; HAMAOKA T; YAGITA H; OKUMURA K; NEBEN S; FUJIWARA H;
Indirizzi:
OSAKA UNIV,SCH MED,BIOMED RES CTR,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,BIOMED RES CTR SUITA OSAKA 565 JAPAN JUNTENDO UNIV,SCH MED TOKYO 113 JAPAN GENET INST INC CAMBRIDGE MA 02140
Titolo Testata:
The Journal of immunology
fascicolo: 12, volume: 160, anno: 1998,
pagine: 5790 - 5796
SICI:
0022-1767(1998)160:12<5790:DIOAFP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAS-MEDIATED APOPTOSIS; INTERLEUKIN-1-BETA CONVERTING-ENZYME; TUMOR-NECROSIS-FACTOR; POLY(ADP-RIBOSE) POLYMERASE; ICE/CED-3 PROTEASE; ICE-LIKE; DEATH; CPP32; IDENTIFICATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Park et al., "DIFFERENTIAL INVOLVEMENT OF A FAS-CPP32-LIKE PROTEASE PATHWAY IN APOPTOSIS OF TCR CD9-COSTIMULATED, NAIVE T-CELLS AND TCR-RESTIMULATED, ACTIVATED T-CELLS/", The Journal of immunology, 160(12), 1998, pp. 5790-5796

Abstract

Our previous study showed that CD9 costimulation of TCR-triggered naive T cells elicits activation ([H-3]TdR incorporation) that is similarto CD28 costimulation; however, unlike CD28 costimulation, CD9 costimulation results in apoptosis of these previously activated T cells. Here, we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated,vith a death pathway involving Fas stimulation and Fas-mediated caspase activation as observed in activation-induced cell death (AICD), In contrast to AICD, the apoptosis resulting from TCR/CD9 stimulation in C57BL/6 T cells was independent of Fas, because this form of apoptosis was not prevented by anti-Fas ligand mAb and wasalso induced in MRL/lpr T cells. AICD was observed at 12 h after the restimulation of activated T cells with anti-CD3 and reached a peak level at 24 h after this restimulation. CPP32-like protease activity wasdetected during AICD, Although TCR/CD9 stimulation-associated apoptosis was observed at 24 h after the stimulation of naive T cells and reached a peak level at 36 h after this stimulation, CPP32-1ike protease activity in these T cells was only marginal at all time points. Nevertheless, both forms of apoptosis were prevented similarly by two different peptide-based caspase inhibitors. These results indicate that the apoptosis that follows the T cell activation which is induced as a result of CD9 costimulation does not involve a Fas-CPP32-like protease pathway, but suggest that different caspase members are likely to be critical in this form of apoptosis.

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Documento generato il 16/07/20 alle ore 19:55:35