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Titolo:
SERIOUS RESPIRATORY ILLNESS ASSOCIATED WITH RHINOVIRUS INFECTION IN APEDIATRIC POPULATION
Autore:
KIM JO; HODINKA RL;
Indirizzi:
UNIV PENN,CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,34TH & CIV CTR BLVDPHILADELPHIA PA 19104 UNIV PENN,CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT PHILADELPHIA PA 19104 UNIV PENN,SCH MED PHILADELPHIA PA 19104 UNIV PENN,CHILDRENS HOSP PHILADELPHIA,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,CHILDRENS HOSP PHILADELPHIA,CLIN VIROL LAB PHILADELPHIA PA 19104
Titolo Testata:
Clinical and diagnostic virology
fascicolo: 1, volume: 10, anno: 1998,
pagine: 57 - 65
SICI:
0928-0197(1998)10:1<57:SRIAWR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; POLYMERASE CHAIN-REACTION; WHEEZY BRONCHITIS; ASTHMA SYMPTOMS; TRACT; VIRUSES; CHILDREN; PRECIPITANTS; DISEASE; INFANTS;
Keywords:
RHINOVIRUS; PEDIATRICS; LOWER RESPIRATORY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.O. Kim e R.L. Hodinka, "SERIOUS RESPIRATORY ILLNESS ASSOCIATED WITH RHINOVIRUS INFECTION IN APEDIATRIC POPULATION", Clinical and diagnostic virology, 10(1), 1998, pp. 57-65

Abstract

Background: Rhinoviruses have long been associated with mild upper respiratory illness in both adults and children. However, the role of rhinoviruses as lower respiratory tract pathogens has not been fully characterized. Previous data suggests that rhinoviruses may cause severe lower respiratory illness in young children or infants. Objectives: The present study describes the clinical presentations, severity of illness and outcomes for a large cohort of pediatric patients with documented rhinovirus infections. Subjects and methods: A retrospective chartreview was done on 93 pediatric patients from whom 101 nasopharyngealor endotracheal specimens were positive by viral culture for a rhinovirus, All patients were hospitalized or seen in the pediatric emergency department at The Children's Hospital of Philadelphia between 1 January, 1990 and 31 May, 1996.Results: Of the 93 patients, 52 were male and 41 female. The age range was 0 days to 18 years with 25 (27%) less than 3 months, 42 (45%) between 3 and 12 months and 26 (28%) over the age of 12 months. Clinical presentations on evaluation in the emergency department or admission included 78 (84%,) patients with acute respiratory illness, 13 (17%) with fever and suspected sepsis and 11 (12%) with other complaints. Reported physical findings on examination included one or more lower respiratory symptoms or signs of acute distress and fever greater than or equal to 38.1 degrees C. A total of 64 (69%)children were noted to have significant past medical histories, including 28 (44%) with prematurity or complicated neonatal courses, 11 (17%) with prior reactive airways, 8 (12%) with congenital cardiac disease and 7 (11%) with neurologic disorders. Of the patients, 29 (31%) were considered to be otherwise healthy children with no underlying dysfunctions. The mean duration of hospitalization for 69 patients admittedwith respiratory illness who did not develop subsequent unrelated complications was 3.7 days. No significant bacterial or fungal pathogens were identified in 91% of the cases. Conclusions: This study shows that rhinoviruses were associated with severe lower respiratory illness and hospitalization in a large pediatric population and that rhinovirusinfection was a complicating factor in those patients with underlyingor predisposing conditions. (C) 1998 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 11:30:13