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Titolo:
EFFECTS OF RED-BLOOD-CELL HYPERAGGREGATION ON THE RAT MICROCIRCULATION BLOOD-FLOW
Autore:
DURUSSEL JJ; BERTHAULT MF; GUIFFANT G; DUFAUX J;
Indirizzi:
UNIV PARIS 07,CNRS URA 343,LAB BIOTHEOL & HYDRODYNAM PHYSICOCHIM,CASE7056,2 PL JUSSIEU F-75005 PARIS FRANCE UNIV PARIS,LAB PHYSIOPATHOL NUTR PARIS FRANCE
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 163, anno: 1998,
pagine: 25 - 32
SICI:
0001-6772(1998)163:1<25:EORHOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CREMASTER MUSCLE; VISCOSITY; AGGREGATION; PARAMETERS; MESENTERY; DEXTRAN;
Keywords:
BLOOD FLOW; CREMASTER; MESENTERY; MICROVASCULAR PRESSURE; RED BLOOD CELL AGGREGATION; TROXERUTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Durussel et al., "EFFECTS OF RED-BLOOD-CELL HYPERAGGREGATION ON THE RAT MICROCIRCULATION BLOOD-FLOW", Acta Physiologica Scandinavica, 163(1), 1998, pp. 25-32

Abstract

This study presents the effects of red blood cell (RBC) hyperaggregation on the blood flow and pressure in the rat mesentery and cremaster network. We exclusively studied in situ non-vasodilated organs, in order to maintain the physiological regulation mechanisms. Dextran 500 was injected at different concentrations to increase RBC aggregation. The aggregation rate was measured on very small blood samples with an erythroaggregameter (SEFAM) which evaluated the disaggregating shear stress (tau(D)) needed to break the RBC aggregates. Microscopic observations and laser Doppler velocimetry were used to quantify the flow rate. The plasmatic dextran concentration (C) increase had different correlated effects: for example, to increased from 3 dynes cm(-2) (for the control sample) to 14 dynes cm(-2) (for C = 75 mu M L-1); the flow ratewas reduced threefold and very large aggregates were observed in the venules; the arteriolar pressure increased while venular pressure decreased. In order to differentiate the effects of RBC hyperaggregation from those of plasma hyperviscosity (due to dextran 500) on microcirculatory blood flow, we injected an RBC antiaggregating drug (troxerutine) (50 or 100 mg kg(-1) IV). The consequences were a high reduction for(tau(D)) (from 14 dynes cm(-2)-9 dynes cm(-2)), smaller aggregates and higher blood flow in the venules. No effect of troxerutine was observed on plasma viscosin/(plasma control: 1,9 cP with or without troxerutine; plasma with dextran at C = 75 mu M L-1: 2,45 cP with or without troxerutine). The results strongly suggest that RBC aggregation has a significant influence on blood flow rate in the microcirculaton/network.

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Documento generato il 20/10/20 alle ore 05:51:13