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Titolo:
ONTOGENY OF A DIURNAL RHYTHM IN ARYLALKYLAMINE-N-ACETYLTRANSFERASE MESSENGER-RNA IN RAT PINEAL-GLAND
Autore:
PFEFFER M; STEHLE JH;
Indirizzi:
JOHANN WOLFGANG GOETHE UNIVERSITAT FRANKFURT,ANAT INST 2,HS 26,THEODOR STERN KAI 7 D-60590 FRANKFURT GERMANY JOHANN WOLFGANG GOETHE UNIVERSITAT FRANKFURT,ANAT INST 2 D-60590 FRANKFURT GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 248, anno: 1998,
pagine: 163 - 166
SICI:
0304-3940(1998)248:3<163:OOADRI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL ASPECTS; MELATONIN RHYTHM; EXPRESSION; REPRESSOR; INCREASE; CREM;
Keywords:
MELATONIN; TRANSCRIPTIONAL REGULATION; CAMP-SIGNALING PATHWAY; DEVELOPMENT; ARYLALKYLAMINE-N-ACETYLTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Pfeffer e J.H. Stehle, "ONTOGENY OF A DIURNAL RHYTHM IN ARYLALKYLAMINE-N-ACETYLTRANSFERASE MESSENGER-RNA IN RAT PINEAL-GLAND", Neuroscience letters, 248(3), 1998, pp. 163-166

Abstract

Melatonin synthesis in the pineal gland of adult rats is linked to cAMP-dependent transcriptional and post-transcriptional regulatory mechanisms affecting its rate-limiting enzyme, the arylalkylamine-N-acetyltransferase (AA-NAT). During development of the pineal gland, neuronal control gains access to the earlier matured cAMP-signaling pathway to shape the day-night rhythm in AA-NAT enzymatic activity. By semiquantitative in situ hybridization we analyzed if the developmental onset ofa rhythmic AA-NAT activity is correlated to a temporally parallel onset in AA-NAT transcription. We found that AA-NAT mRNA levels in rat pineal gland become rhythmic at postnatal day 5. Thus, AA-NAT gene transcription in rat pineal gland starts to show day-night differences shortly prior to the appearance of a rhythmic AA-NAT activity. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:31:04