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Titolo:
THE ACTIONS OF EXOGENOUS DEHYDROEPIANDROSTERONE IN EXPERIMENTAL-ANIMALS AND HUMANS
Autore:
SVEC F; PORTER JR;
Indirizzi:
LOUISIANA STATE UNIV,DEPT MED,SCH MED,OBES RES PROGRAM,SECT ENDOCRINOL,1542 TULANE AVE NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,DEPT PHYSIOL,SCH MED,OBES RES PROGRAM,SECT ENDOCRINOL NEW ORLEANS LA 70112
Titolo Testata:
Proceedings of the Society for Experimental Biology and Medicine
fascicolo: 3, volume: 218, anno: 1998,
pagine: 174 - 191
SICI:
0037-9727(1998)218:3<174:TAOEDI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE ZUCKER RATS; POSTMENOPAUSAL WOMEN; DIETARY DEHYDROEPIANDROSTERONE; ORAL DEHYDROEPIANDROSTERONE; RHESUS-MONKEY; FOOD-INTAKE; ANTIGLUCOCORTICOID ACTION; PEROXISOME PROLIFERATION; CARDIOVASCULAR-DISEASE; RECEPTOR-BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
F. Svec e J.R. Porter, "THE ACTIONS OF EXOGENOUS DEHYDROEPIANDROSTERONE IN EXPERIMENTAL-ANIMALS AND HUMANS", Proceedings of the Society for Experimental Biology and Medicine, 218(3), 1998, pp. 174-191

Abstract

Dehydroepiandrosterone (DHEA) is the major adrenal steroid of young adults; however, its physiologic functions, if any, are not known. The purpose of this review is to evaluate the current literature in which DHEA was administered to either humans or experimental animals to discern what these functions might be. Reports are divided into five areas: neurologic, immunologic, cardiovascular, oncologic, and metabolic. Particular attention is paid to the dosage and route of administration. This type of analysis shows that at the lowest doses, DHEA has effects on neurologic and immunologic tissues, suggesting that these two sites may be physiologic targets. DHEA also affects cardiologic and metabolic functions as well as tumor growth, but such actions require higher doses and may reflect 'pharmacologic' activities. It is proposed that DHEA's pattern of activity represents a new class of steroid hormones, the ''Regnantoids. '' Further progress in the endocrinology of this family of steroids may only come when synthetic, long-acting analogs of DHEA are available for in vitro studies to allow correlations between hormone action and receptor binding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:25:23