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Titolo:
INTERCELLULAR COMMUNICATION VIA GAP JUNCTION CHANNELS
Autore:
HULSER DF; ECKERT R; IRMER U; KRISCIUKAITIS A; MINDERMANN A; PLEISS J; REHKOPF B; SHAROVSKAYA J; TRAUB O;
Indirizzi:
UNIV STUTTGART,INST BIOL,BIOPHYS ABT D-70550 STUTTGART GERMANY UNIV AUCKLAND,SCH BIOL SCI AUCKLAND NEW ZEALAND KAUNAS MED ACAD KAUNAS LITHUANIA UNIV STUTTGART,INST TECH BIOCHEM D-70569 STUTTGART GERMANY MOSCOW MV LOMONOSOV STATE UNIV,BELOZERSKY INST MOSCOW RUSSIA UNIV BONN,INST GENET,ABT MOL GENET D-53117 BONN GERMANY
Titolo Testata:
Bioelectrochemistry and bioenergetics
fascicolo: 1, volume: 45, anno: 1998,
pagine: 55 - 65
SICI:
0302-4598(1998)45:1<55:ICVGJC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL CHANNELS; FUNCTIONAL EXPRESSION; HELA-CELLS; MOLECULAR-CLONING; MAMMALIAN HEART; FROZEN; CONNEXIN37; RESISTANCE; CULTURES; PROTEIN;
Keywords:
GAP JUNCTION CHANNEL; CONNEXIN; OPEN PROBABILITY; IMMUNOGOLD LABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Hulser et al., "INTERCELLULAR COMMUNICATION VIA GAP JUNCTION CHANNELS", Bioelectrochemistry and bioenergetics, 45(1), 1998, pp. 55-65

Abstract

Gap junction channels maintain cell-cell communication and thus are essential for the functional co-ordination of tissues and organs. Thesechannels are composed of connexins, a membrane protein family with more than a dozen members. Properties of gap junction channels are best studied with connexin deficient cells which are transfected with a selected connexin gene. We investigated connexin transfected HeLa cells with electronmicroscopical (immunogold labelling of freeze fractured replicas) and electrophysiological (patch clamp and dye transfer) techniques. Our results revealed functional gap junction channels outside ofquasi-crystalline plaques and give further evidence for different regulations of channel gating for different connexin isoforms by voltage polarity of the transjunctional voltage and by intracellular proton concentration. Our model of gap junction channels indicates connexins that are integrated in the membrane lipids with different tilt angles and a ring of positive and negative charges within the pore wall that might act as a selectivity filter. (C) 1998 Elsevier Science S.A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:34:40