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Titolo:
PSAMMOMA BODIES IN FINE-NEEDLE ASPIRATES OF THE THYROID - PREDICTIVE VALUE FOR PAPILLARY CARCINOMA
Autore:
ELLISON E; LAPUERTA F; MARTIN SE;
Indirizzi:
UNIV SO CALIF,DEPT PATHOL,NOR 2420,HLTH SCI CAMPUS LOS ANGELES CA 90033 UNIV SO CALIF,DEPT PATHOL LOS ANGELES CA 90033 UNIV SO CALIF,DEPT MED LOS ANGELES CA 00000
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 3, volume: 84, anno: 1998,
pagine: 169 - 175
SICI:
0008-543X(1998)84:3<169:PBIFAO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GOITER;
Keywords:
FINE-NEEDLE ASPIRATION; THYROID; PSAMMOMA BODY; CALCIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Ellison et al., "PSAMMOMA BODIES IN FINE-NEEDLE ASPIRATES OF THE THYROID - PREDICTIVE VALUE FOR PAPILLARY CARCINOMA", CANCER CYTOPATHOLOGY, 84(3), 1998, pp. 169-175

Abstract

BACKGROUND. Although characteristic of thyroid papillary carcinoma, psammoma bodies occasionally arise in benign or nonpapillary lesions. Their predictive value in fine-needle aspirates (FNA), without other features suggestive of papillary carcinoma, is uncertain. METHODS. This retrospective study determined the frequency of psammoma bodies and other calcifications in 313 FNAs and 69 resected thyroids; positive predictive value, sensitivity, and specificity were calculated and compared with a triad of characteristic cytologic features (papillary fronds,nuclear ridges/grooves, and intranuclear inclusions). Psammoma bodiesfrom benign and malignant conditions were assessed for differentiating architectural or staining characteristics. RESULTS. Psammoma bodies were found in only 8 of 313 FNAs. Their positive predictive value for papillary carcinoma was 50%, the rest arising from multinodular goiters. By contrast, the positive predictive value of combined cytologic features was 100%. These features were also much more sensitive, presentin 80% of papillary carcinomas compared with 14% with psammoma bodies. The psammoma bodies of papillary carcinoma could not be differentiated from those of other lesions either by staining characteristics or by architecture. Other types of calcifications also were present in diverse conditions, and did not discriminate among them. CONCLUSIONS. Isolated psammoma bodies are an unreliable predictor of papillary carcinoma in the absence of cytologic features. In view of the relatively lowaggressiveness of papillary carcinoma in most age groups, repeat fine-needle aspiration and clinical con elation are recommended prior to consideration of surgery. (C) 1998 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:41:29