Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRECORE STOP CODON MUTANT IN CHRONIC HEPATITIS-B VIRUS-INFECTION IN CHILDREN - ITS RELATION TO HEPATITIS-B E-SEROCONVERSION AND MATERNAL HEPATITIS-B SURFACE-ANTIGEN
Autore:
CHANG MH; HSU HY; NI YH; TSAI KS; LEE PI; CHEN PJ; HSU YL; CHEN DS;
Indirizzi:
NATL TAIWAN UNIV HOSP,COLL MED,DEPT PEDIAT,7 CHUNG SHAN S RD TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,COLL MED,DEPT LAB MED TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,COLL MED,HEPATITUS RES CTR TAIPEI TAIWAN
Titolo Testata:
Journal of hepatology
fascicolo: 6, volume: 28, anno: 1998,
pagine: 915 - 922
SICI:
0168-8278(1998)28:6<915:PSCMIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT-HEPATITIS; VERTICAL TRANSMISSION; UNITED-STATES; MUTATIONS; REGION; REACTIVATION; CARRIERS; DNA; CHILDHOOD; ANTIBODY;
Keywords:
AMPLIFIED CREATED RESTRICTION SITE; HEPATITIS B E ANTIGEN; HEPATITIS B E SEROCONVERSION; POLYMERASE CHAIN REACTION; PRECORE STOP CODON MUTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Chang et al., "PRECORE STOP CODON MUTANT IN CHRONIC HEPATITIS-B VIRUS-INFECTION IN CHILDREN - ITS RELATION TO HEPATITIS-B E-SEROCONVERSION AND MATERNAL HEPATITIS-B SURFACE-ANTIGEN", Journal of hepatology, 28(6), 1998, pp. 915-922

Abstract

Background/Aims: The aims of this study were to investigate the significance of the precore stop codon mutant in the natural course of hepatitis B virus infection in children, and the influence of maternal transmission. Methods: Sequential sera from 80 hepatitis B virus carrier children both before and after e seroconversion during long-term follow-up were studied using the polymerase chain reaction-amplification created restriction site method. Direct sequencing of the precore regionwas performed in 89 sera from 32 of the 80 children. Results: The precore stop codon mutant coexisting with wild strain was found in 10% ofchildren initially, and later in 25% of children before e seroconversion, After e seroconversion, wild type was still present in 75% and mutant in 39% of children at the end of follow-up. The mutant alone was present in 15% of anti-HBe positive children without concomitant aminotransferase elevation. Children with earlier emergence of this mutant tended to have higher peak aminotransferase levels. This mutant emerged less frequently in children of hepatitis B virus carrier mothers (37.5%) than in those of non-carrier mothers (65%) (p<0.05). Conclusions:These observations suggest that this mutant is selected by host immune pressure, but is not an initiator in the loss of immune tolerance during childhood chronic hepatitis B virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:07:27