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Titolo:
DEVELOPMENT OF A NOVEL OSTEOCHONDRAL GRAFT FOR CARTILAGE REPAIR
Autore:
TOOLAN BC; FRENKEL SR; PEREIRA DS; ALEXANDER H;
Indirizzi:
HOSP JOINT DIS & MED CTR,INST ORTHOPAED,MUSCULOSKELETAL RES CTR,301 E17TH ST NEW YORK NY 10003 HOSP JOINT DIS & MED CTR,INST ORTHOPAED,MUSCULOSKELETAL RES CTR NEW YORK NY 10003 HOSP JOINT DIS & MED CTR,INST ORTHOPAED,DEPT ORTHOPAED SURG NEW YORK NY 10003
Titolo Testata:
Journal of biomedical materials research
fascicolo: 2, volume: 41, anno: 1998,
pagine: 244 - 250
SICI:
0021-9304(1998)41:2<244:DOANOG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT ARTICULAR-CARTILAGE; DEFECTS; KNEE; SURFACES; IMPLANT; CULTURE; TISSUE; JOINT; BONE;
Keywords:
CARTILAGE REPAIR; OSTEOCHONDRAL GRAFT; CHONDROCYTE TRANSPLANTATION; ARTICULAR CARTILAGE DEFECTS; ANIMAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Toolan et al., "DEVELOPMENT OF A NOVEL OSTEOCHONDRAL GRAFT FOR CARTILAGE REPAIR", Journal of biomedical materials research, 41(2), 1998, pp. 244-250

Abstract

This study reports the development of a novel osteochondral graft forcartilage repair. A technique of proteoglycan extraction via timed enzymatic digestion with hyaluronidase and trypsin and subsequent professing with a chloroform-methanol solution to remove cellular debris from a fresh-frozen bovine osteochondral sample is a method described to prepare a stable biological carrier of low immunogenicity. Lyophilization of the carrier followed by rehydration in a suspension of lapine chondrocytes produced a chimeric xenograft that succeeded in vivo in enhancing cartilage repair. In a pilot study, full-thickness articular cartilage defects treated with these xenografts demonstrated improved healing compared to untreated defects or defects treated with unseeded grafts at 2, 6, and 12 weeks postimplantation. The xenograft provoked a mild inflammatory response; however this did not impede the repair process. Further investigation of this novel chimeric xenograft eventually may yield a method of cartilage repair superior to current methodsof treatment. (C) 1998 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:47:19