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Titolo:
EFFECT OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS ON THE ANTICONVULSIVE ACTIVITY OF VALPROATE AND DIPHENYLHYDANTOIN AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE
Autore:
KAMINSKI R; KOZICKA M; PARADATURSKA J; DZIKI M; KLEINROK Z; TURSKI WA; CZUCZWAR SJ;
Indirizzi:
MED UNIV SCH,DEPT PHARMACOL & TOXICOL,JACZEWAKIEGO 8 PL-20090 LUBLIN POLAND MED UNIV SCH,DEPT PHARMACOL & TOXICOL PL-20090 LUBLIN POLAND INST RURAL MED,DEPT CLIN TOXICOL PL-20950 LUBLIN POLAND MED UNIV SCH,DEPT RHEUMATOL PL-20090 LUBLIN POLAND
Titolo Testata:
Pharmacological research
fascicolo: 5, volume: 37, anno: 1998,
pagine: 375 - 381
SICI:
1043-6618(1998)37:5<375:EONADO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ARACHIDONIC-ACID; KAINIC ACID; BRAIN; RAT; PHARMACOKINETICS; SALICYLATE; STIMULI; GERBILS;
Keywords:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTIEPILEPTICS; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R. Kaminski et al., "EFFECT OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS ON THE ANTICONVULSIVE ACTIVITY OF VALPROATE AND DIPHENYLHYDANTOIN AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE", Pharmacological research, 37(5), 1998, pp. 375-381

Abstract

Prostaglandins and their inhibitors may affect convulsive phenomena. Thus, the aim of this study was to examine possible interactions between non-steroidal anti-inflammatory drugs and two conventional antiepileptic drugs in terms of their anticonvulsive activity and side-effects. Also, the plasma levels of antiepileptics were measured in order to delineate possible pharmacokinetic interactions. The following non-steroidal anti-inflammatory drugs (NSAIDs) were studied: acetylsalicylic acid, ibuprofen, indomethacin, metamizole, paracetamol and piroxicam. None of these drugs affected the threshold for electroconvulsions. However, all NSAIDs studied enhanced the protective activity of valproatemagnesium against maximal electroshock-induced seizures. Only ibuprofen and piroxicam enhanced the anticonvulsive activity of diphenylhydantoin. Ibuprofen decreased the ED50 value of valproate (for the induction of motor impairment) in the rotorod test, whilst piroxicam reduced the ED50 value of valproate in rotorod and chimney tests. Diphenylhydantoin combined with either ibuprofen or piroxicam did not cause any motor impairment in these tests. The total plasma level of valproate andfree plasma level of diphenylhydantoin remained unchanged in the presence of all studied NSAIDs. These data demonstrate that NSAIDs could enhance the protective activity of antiepileptics. However, in case of valproate it may be associated with the severe side effects. (C) 1998 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:24:37