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Titolo:
RESPONSES TO STRESS AND NOVELTY IN ADULT RATS BORN VAGINALLY, BY CESAREAN-SECTION OR BY CESAREAN-SECTION WITH ACUTE ANOXIA
Autore:
BOKSA P; WILSON D; ROCHFORD J;
Indirizzi:
DOUGLAS HOSP,RES CTR,6875 LASALLE BLVD VERDUN PQ H4H 1R3 CANADA MCGILL UNIV,DEPT PSYCHIAT MONTREAL PQ CANADA MCGILL UNIV,DEPT NEUROL & NEUROSURG MONTREAL PQ CANADA
Titolo Testata:
Biology of the neonate
fascicolo: 1, volume: 74, anno: 1998,
pagine: 48 - 59
SICI:
0006-3126(1998)74:1<48:RTSANI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTICAL-LESIONS; ELEVATED PLUS-MAZE; ANESTHESIA; REACTIVITY; ASPHYXIA; TIMIDITY; BEHAVIOR; DELIVERY; STIMULI; ANXIETY;
Keywords:
PERINATAL HYPOXIA; CESAREAN SECTION; STRESS; NOVELTY; BEHAVIOR; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P. Boksa et al., "RESPONSES TO STRESS AND NOVELTY IN ADULT RATS BORN VAGINALLY, BY CESAREAN-SECTION OR BY CESAREAN-SECTION WITH ACUTE ANOXIA", Biology of the neonate, 74(1), 1998, pp. 48-59

Abstract

The aim of this study was to test the hypothesis that alterations in birth conditions, specifically vaginal birth vs, birth by Cesarean section (C-section) vs. birth by C-section with an added period of acute global anoxia, produces long-term differences in behavioral responses to stress or novelty in the rat at adulthood. In comparison to animalsborn by rapid C-section alone, animals born by C-section with 10 or 15 min of added anoxia were significantly more immobile during forced swim stress administered for 6 trials over several weeks. In a step-down passive avoidance task, there were no group differences in acquisition or retention of the avoidance response. However, when initially placed in the passive avoidance apparatus before delivery of shock, animals born by C-section with 15 min of anoxia required significantly morepretrials to step down from the wooden platform, than did vaginally born or C-sectioned animals, No group differences were observed on measures of exploratory behavior in an elevated plus-maze or of approach behavior either to food or to a novel object in an open field. These findings suggest that birth conditions which include a degree of perinatal hypoxia can contribute to variability in selective responses to stress and novelty in the adult rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:27:16