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Titolo:
ARGINASE AI IS UP-REGULATED IN ACUTE IMMUNE COMPLEX-INDUCED INFLAMMATION
Autore:
WADDINGTON SN; MOSLEY K; COOK HT; TAM FWK; CATTELL V;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,DEPT HISTOPATHOL,ST MARYS CAMPUS LONDON W2 1PG ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,DEPT HISTOPATHOL LONDON W2 1PG ENGLAND HAMMERSMITH HOSP,DEPT HISTOPATHOL LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,RENAL SECT LONDON W12 0NN ENGLAND
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 247, anno: 1998,
pagine: 84 - 87
SICI:
0006-291X(1998)247:1<84:AAIUIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; RAT; MACROPHAGES; EXPRESSION; CDNA; GLOMERULONEPHRITIS; INDUCTION; CLONING; TISSUES; GROWTH;
Keywords:
ARGINASE; GLOMERULONEPHRITIS; NITRIC OXIDE; MESANGIAL CELLS; NEUTROPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Waddington et al., "ARGINASE AI IS UP-REGULATED IN ACUTE IMMUNE COMPLEX-INDUCED INFLAMMATION", Biochemical and biophysical research communications, 247(1), 1998, pp. 84-87

Abstract

Previous studies have shown high arginase activity at inflammatory sites. Arginase converts L-arginine to L-ornithine, sharing a common substrate with nitric oxide synthase. It exists as two isoforms, Al and AII. While the function of liver arginase (AI) in ureagenesis has been defined, the role and isoform of arginase in cells without a complete urea cycle are unknown. We therefore determined arginase isoform mRNA expression in glomerular acute immune complex inflammation, and its cultured constituent cells. Al was induced in nephritic glomeruli, and in mesangial cells stimulated with IL-4 and cAMP, and was present in elicited neutrophils and macrophages, AU. was constitutively expressed. Our data strongly suggest that AI, thought to be restricted to the liver; accounts for high arginase activity at inflammatory sites where itmay limit high output nitric oxide production and generate polyaminesand proline essential for cell proliferation and matrix production. This identification of Al in inflamed tissue is an important step for understanding the consequences of increased arginase activity. (C) 1998Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:39:34