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Titolo:
PSYLLIUM, NOT PECTIN OR GUAR GUM, ALTERS LIPOPROTEIN AND BILIARY BILE-ACID COMPOSITION AND FECAL STEROL EXCRETION IN THE HAMSTER
Autore:
TRAUTWEIN EA; RIECKHOFF D; KUNATHRAU A; ERBERSDOBLER HF;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,INST HUMAN NUTR & FOOD SCI,DUSTERNBROOKER WEG 17 D-24105 KIEL GERMANY
Titolo Testata:
Lipids
fascicolo: 6, volume: 33, anno: 1998,
pagine: 573 - 582
SICI:
0024-4201(1998)33:6<573:PNPOGG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL 7-ALPHA-HYDROXYLASE ACTIVITY; LOW-DENSITY-LIPOPROTEIN; LOWERING ACTION; DIETARY FIBER; GUINEA-PIGS; PLASMA-LIPOPROTEINS; RECEPTOR ACTIVITY; LDL-CHOLESTEROL; DOSE-RESPONSE; CHOLESTYRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Trautwein et al., "PSYLLIUM, NOT PECTIN OR GUAR GUM, ALTERS LIPOPROTEIN AND BILIARY BILE-ACID COMPOSITION AND FECAL STEROL EXCRETION IN THE HAMSTER", Lipids, 33(6), 1998, pp. 573-582

Abstract

Different soluble dietary fibers known to alter cholesterol metabolism were fed to golden Syrian hamsters, and their specific impact on lipoproteins, biliary bile acid profile, and fecal sterol excretion was evaluated. Semipurified diets containing 20% fat; 0.12% cholesterol; and 8% of psyllium (PSY); high (hePE) and low (lePE) esterified pectin; or high (hvGG) and low (IvGG) viscous guar gum were fed for 5 wk. Compared to central, PSY caused a significant reduction in plasma cholesterol (2.9 +/- 0.5 vs. 5.5 +/- 0.5 mmol/L), whereas hePE, lePE, hvGG, orIvGG had no apparent effect on plasma lipids. Hepatic total and esterified cholesterol were substantially decreased with PSY, pectin and guar gum, whereby PSY produced the most pronounced effect. Distinctive changes existed in the bile acid profile related to the different fibers. In contrast to pectin and guar gum, PSY caused a significant increase in the cholate:chenodeoxycholate and the glycine:taurine conjugation ratio. Pectin and guar gum did not alter daily fecal neutral sterol excretion while PSY caused a 90% increase due to a higher fecal output. Daily fecal bile acid excretion and total fecal bile acid concentration were significantly increased by PSY, whereas hePE, lePE, hvGG, andIvGG revealed no or only minor effects. Taken together, the disparatehypocholesterolemic effects of PSY, pectin, and guar gum on cholesterol and bile acid metabolism in the hamster are possibly related to different physicochemical properties, e.g., viscosity and susceptibility to fermentation, affecting the fiber-mediated action in the intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:13:25