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Titolo: EFFECT OF MEDIUM-CHAIN AND LONG-CHAIN TRIGLYCERIDES ON LOWER ESOPHAGEAL SPHINCTER PRESSURE - ROLE OF CCK
Autore: LEDEBOER M; MASCLEE AAM; BIEMOND I; LAMERS CBHW;
- Indirizzi:
- LEIDEN UNIV,MED CTR,DEPT GASTROENTEROL HEPATOL,BLDG 1,C4-P,POB 9600 NL-2300 RC LEIDEN NETHERLANDS LEIDEN UNIV,MED CTR,DEPT GASTROENTEROL HEPATOL NL-2300 RC LEIDEN NETHERLANDS
- Titolo Testata:
- American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 6,
volume: 37,
anno: 1998,
pagine: 1160 - 1165
- SICI:
- 0193-1857(1998)37:6<1160:EOMALT>2.0.ZU;2-V
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- CHOLECYSTOKININ-RECEPTOR ANTAGONIST; GALLBLADDER VOLUME; PANCREATIC INSUFFICIENCY; PLASMA CHOLECYSTOKININ; MOLECULAR-FORMS; LOXIGLUMIDE; CONTRACTION; FAT; PENTAGASTRIN; RELAXATION;
- Keywords:
- DIETARY FAT; ESOPHAGEAL MOTILITY; GALLBLADDER MOTILITY; CHOLECYSTOKININ RECEPTOR ANTAGONIST;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 36
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- M. Ledeboer et al., "EFFECT OF MEDIUM-CHAIN AND LONG-CHAIN TRIGLYCERIDES ON LOWER ESOPHAGEAL SPHINCTER PRESSURE - ROLE OF CCK", American journal of physiology: Gastrointestinal and liver physiology, 37(6), 1998, pp. 1160-1165
Abstract
Fat meals are known to decrease lower esophageal sphincter (LES) pressure, possibly through postprandial CCK release. Dietary fat consists mainly of long-chain triglycerides (LCT), which potently stimulate CCKsecretion. This effect contrasts with that of medium-chain triglycerides (MCT), which do not induce CCK release. We recorded LES pressure and gallbladder volume in six healthy subjects on five separate occasions during intraduodenal administration of 1) saline control, 2) LCT, 3) MCT, 4) LCT during intravenous infusion of the CCK receptor antagonist loxiglumide, and 5) MCT together with loxiglumide. LES pressure decreased significantly during administration of both LCT and MCT. Loxiglumide completely prevented the reduction in LES pressure during intraduodenal LCT, but; not during intraduodenal MCT. Gallbladder volume decreased during LCT, but not during MCT. It is concluded that intraduodenal administration of equimolar amounts of both LCT and MCT significantly reduces LES pressure. The effect of LCT on LES pressure is mediated by CCK. The effect of MCT is not dependent on CCK, since MCT does not release CCK and loxiglumide does not prevent the MCT-induced reduction in LES pressure.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:39:34