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Titolo:
[PHE(1)PSI(CH2-NH)GLY(2)]NOCICEPTIN-(1-13)-NH2 IS AN AGONIST OF THE NOCICEPTIN (ORL1) RECEPTOR
Autore:
BUTOUR JL; MOISAND C; MOLLEREAU C; MEUNIER JC;
Indirizzi:
INST PHARMACOL & BIOL STRUCT,CNRS,UPR 9062,UNITE NEUROPHARMACOL MOL,205 ROUTE NARBONNE F-31077 TOULOUSE 4 FRANCE INST PHARMACOL & BIOL STRUCT,CNRS,UPR 9062,UNITE NEUROPHARMACOL MOL F-31077 TOULOUSE 4 FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 349, anno: 1998,
pagine: 5 - 6
SICI:
0014-2999(1998)349:1<5:[IAAOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
NOCICEPTIN PSEUDOPEPTIDE ANALOG; NOCICEPTIN RECEPTOR; HUMAN BRAIN; CAMP SYNTHESIS INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Butour et al., "[PHE(1)PSI(CH2-NH)GLY(2)]NOCICEPTIN-(1-13)-NH2 IS AN AGONIST OF THE NOCICEPTIN (ORL1) RECEPTOR", European journal of pharmacology, 349(1), 1998, pp. 5-6

Abstract

[Phe(1)psi(CH2-NH)Gly(2)]nociceptin-(1-13)-NH2, a pseudopeptide analog of nociceptin, has been shown to be a selective 'antagonist' of the nociceptin receptor in the isolated guinea pig ileum and mouse vas deferens preparations (Guerrini et al., 1998. Br. J. Pharmacol. 123, 163-165). However, in recombinant chinese hamster ovary cells expressing the human nociceptin receptor, we find that the pseudopeptide is a potent (IC50 = 7.5 nM) and fully efficacious inhibitor of forskolin-induced accumulation of cAMP, thus behaving as a pure 'agonist' rather than an antagonist of the receptor. The contrary behaviour of the pseudopeptide in smooth muscle and transformed cells may suggest that differentnociceptin receptor types are being addressed in the two systems. (C)1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:40:36