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Titolo:
QUINPIROLE ATTENUATES STRIATAL C-FOS INDUCTION BY 5-MT, OPIOID AND MUSCARINIC RECEPTOR AGONISTS
Autore:
COOK DF; WIRTSHAFTER D;
Indirizzi:
UNIV ILLINOIS,DEPT PSYCHOL MC 285,1007 W HARRISON ST CHICAGO IL 60607 UNIV ILLINOIS,DEPT PSYCHOL MC 285 CHICAGO IL 60607
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 349, anno: 1998,
pagine: 41 - 47
SICI:
0014-2999(1998)349:1<41:QASCIB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; DOPAMINE-RECEPTORS; EXPRESSION; NEURONS; GENE; IMMUNOREACTIVITY; ACTIVATION; DORSAL; D1; RELEASE;
Keywords:
IMMEDIATE EARLY GENE; DOPAMINE D-2 RECEPTOR; ACETYLCHOLINE; FENFLURAMINE; TFMPP -(3-TRIFLUOROMETHYLPHENYL)PIPERAZINEHYDROCHLORIDE); RU-24969; DOI METHOXY-4-IODOPHENYL)-2-AMINOPROPANEHYDROCHLORIDE) PILOCARPINE; MORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Cook e D. Wirtshafter, "QUINPIROLE ATTENUATES STRIATAL C-FOS INDUCTION BY 5-MT, OPIOID AND MUSCARINIC RECEPTOR AGONISTS", European journal of pharmacology, 349(1), 1998, pp. 41-47

Abstract

Pretreatment with the dopamine D, receptor agonist quinpirole (0.025-2.5 mg/kg) produced a marked, dose-dependent, attenuation of the striatal Fos expression induced by the serotonin (5-Hydroxytryptamine, 5-HT) releasing agent fenfluramine (25 mg/kg). Quinpirole (2.5 mg/kg) was also able to drastically attenuate the striatal Fos response produced by injections of the direct 5-HT1/2 receptor agonist N-(3-trifluoromethylphenyl)piperazine hydrochloride (TFMPP) (5 mg/kg), the selective 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI) (6.64 mg/kg), the 5-HT(1A/1B )receptor agonist RU-24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)1 H-indole) (5 mg/kg),the mu-opioid receptor agonist morphine (5 mg/kg) and the muscarinic cholinergic receptor agonist pilocarpine (50 mg/kg). These results arein marked contrast to the previously reported ability of quinpirole to potentiate the response to D-1 dopamine receptor agonists and demonstrate that stimulation of D-2-like receptors can have differential effects on the Fos responses induced by various drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 06:51:02