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Titolo:
COMBINED EFFECTS OF SIMULTANEOUS EXPOSURE TO TOLUENE AND ETHANOL ON AUDITORY FUNCTION IN RATS
Autore:
CAMPO P; LATAYE R; COSSEC B; VILLETTE V; ROURE M; BARTHELEMY C;
Indirizzi:
INST NATL RECH & SECUR,LAB MULTINUISANCES,AVE BOURGOGNE,BP 27 F-54501VANDOEUVRE NANCY FRANCE
Titolo Testata:
Neurotoxicology and teratology
fascicolo: 3, volume: 20, anno: 1998,
pagine: 321 - 332
SICI:
0892-0362(1998)20:3<321:CEOSET>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORINATED HYDROCARBONS; METABOLISM; ALCOHOL; HEARING; XYLENE; BLOOD;
Keywords:
TOLUENE; ETHANOL; HEARING LOSS; COCHLEA; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P. Campo et al., "COMBINED EFFECTS OF SIMULTANEOUS EXPOSURE TO TOLUENE AND ETHANOL ON AUDITORY FUNCTION IN RATS", Neurotoxicology and teratology, 20(3), 1998, pp. 321-332

Abstract

Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the, second one was dailygavaged with a saline solution of ethanol (4 g/kg, 4 weeks), and the last group was simultaneously exposed to both toluene and ethanol. Auditory function was tested by recording brain stem (inferior colliculus) auditory-evoked potentials for audiometric frequencies ranging from 2 to 32 kHz. Urinary hippuric acid was dosed to check the toluene metabolism during the experiments. Ethanol clearly modified the toluene metabolism in the present experimental conditions. As a result, the hearing loss induced by a simultaneous exposure to both ethanol and toluene was larger than that induced by exposure to toluene alone. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:38:20