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Titolo:
THE NEURODEVELOPMENT HYPOTHESIS OF SCHIZOPHRENIA - CLINICAL-EVIDENCE AND ANIMAL-MODELS
Autore:
ELLENBROEK BA; COOLS AR;
Indirizzi:
UNIV NIJMEGEN,DEPT PSYCHONEUROPHARMACOL,POB 9101 NL-6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
Neuroscience research communications
fascicolo: 3, volume: 22, anno: 1998,
pagine: 127 - 136
SICI:
0893-6609(1998)22:3<127:TNHOS->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL HIPPOCAMPAL DAMAGE; HIGH-RISK SAMPLE; PRENATAL EXPOSURE; PREPULSE INHIBITION; LATENT INHIBITION; SOCIAL-ISOLATION; OBSTETRIC COMPLICATIONS; PREMORBID ADJUSTMENT; ADULT SCHIZOPHRENIA; MATERNAL SEPARATION;
Keywords:
ANIMAL MODELS; HIPPOCAMPUS; ISOLATION REARING; MATERNAL DEPRIVATION; NEURODEVELOPMENTAL HYPOTHESIS; SCHIZOPHRENIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
97
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Ellenbroek e A.R. Cools, "THE NEURODEVELOPMENT HYPOTHESIS OF SCHIZOPHRENIA - CLINICAL-EVIDENCE AND ANIMAL-MODELS", Neuroscience research communications, 22(3), 1998, pp. 127-136

Abstract

Although the cause of schizophrenia is not fully elucidated, there isincreasing evidence that this severe psychiatric illness may result from a disturbance early in development. Evidence for this so called ''neurodevelopmental hypothesis'' comes from a variety of sources, including epidemiological, gynaecological, psychological and pathological data. The present review summarises some of these data. The recognitionthat schizophrenia may result from early (pre- and/or postnatal) abnormalities in development has also off a new approach to animal modelling. Until recently, animal researchers have invariably used drugs likeamphetamine or phencyclidine to induce a ''schizophrenia-like'' condition. In the last few years at least three different models using early manipulations have been reported. These models are reviewed and compared with each other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:08:20