Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TOPICAL METRONIDAZOLE MAINTAINS REMISSIONS OF ROSACEA
Autore:
DAHL MV; KATZ I; KRUEGER GG; MILLIKAN LE; ODOM RB; PARKER F; WOLF JE; ALY R; BAYLES C; REUSSER B; WEIDNER M; COLEMAN E; PATRIGNELLI R; TULEY MR; BAKER MO; HERNDON JH; CZERNIELEWSKI JM;
Indirizzi:
GALDERMA LABS INC,3000 ALTA MESA BLVD,SUITE 300 FT WORTH TX 76163 UNIV MINNESOTA,DEPT DERMATOL MINNEAPOLIS MN 55455 MINNESOTA CLIN STUDY CTR MINNEAPOLIS MN 00000 UNIV UTAH,DIV DERMATOL SALT LAKE CITY UT 00000 TULANE UNIV,DEPT DERMATOL NEW ORLEANS LA 70118 UNIV CALIF SAN FRANCISCO,DEPT DERMATOL SAN FRANCISCO CA 94143 OREGON HLTH SCI UNIV,DEPT DERMATOL PORTLAND OR 97201 BAYLOR MED CTR,DEPT DERMATOL HOUSTON TX 00000 SW MED SCH DALLAS TX 00000
Titolo Testata:
Archives of dermatology
fascicolo: 6, volume: 134, anno: 1998,
pagine: 679 - 683
SICI:
0003-987X(1998)134:6<679:TMMROR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREAM; TETRACYCLINE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M.V. Dahl et al., "TOPICAL METRONIDAZOLE MAINTAINS REMISSIONS OF ROSACEA", Archives of dermatology, 134(6), 1998, pp. 679-683

Abstract

Background: Rosacea is a chronic skin disease that requires long-termtherapy. Oral antibiotics and topical metronidazole successfully treat rosacea. Because long-term use of systemic antibiotics carries risksfor systemic complications and adverse reactions, topical treatments are preferred. Objective: To determine if the use of topical metronidazole gel (Metrogel) could prevent relapse of moderate to severe rosacea. Design: A combination of oral tetracycline and topical metronidazole gel was used to treat 113 subjects with rosacea (open portion of thestudy). Successfully treated subjects (n = 88) entered a randomized, double-blind, placebo-controlled study applying either 0.75% topical metronidazole gel (active agent) or topical metronidazole vehicle gel (placebo) twice daily (blinded portion of the study). Setting: Subjectswere enrolled at 6 separate sites in large cities at sites associatedwith major medical centers. Subjects: One hundred thirteen subjects with at least 6 inflammatory papules and pustules, moderate to severe facial erythema, and telangiectasia entered the open phase of the study. Eighty-eight subjects responded to treatment with systemic tetracycline and topical metronidazole gel as measured by at least a 70% reduction in the number of inflammatory lesions. These subjects were randomized to receive 1 of 2 treatments: either 0.75% metronidazole gel or placebo gel. Interventions: Subjects were evaluated monthly for up to 6 months to determine relapse rates. Main Outcome Measures: Inflammatorypapules and pustules were counted at each visit. Relapse was determined by the appearance of a clinically significant increase in the number of papules and pustules. Prominence of telangiectases and dryness (roughness and scaling) were also observed. Results: In the open phase, treatment with tetracycline and metronidazole gel eliminated all papules and pustules in 67 subjects (59%). The faces of 104 subjects (92%) displayed fewer papules and pustules after treatment, and 82 subjects (73%) exhibited less erythema. In the randomized double blind phase, the use of topical metronidazole significantly prolonged the disease-free interval and minimized recurrence compared with subjects treated with the vehicle. Eighteen (42%) of 43 subjects applying the vehicle experienced relapse, compared with 9 (23%) of 39 subjects applying metronidazole gel (P<.05). The metronidazole group had fewer papules and/or pustules after 6 months of treatment (P<.01). Relapse of erythema alsooccurred less often in subjects treated with metronidazole (74% vs 55%). Conclusion: In a majority of subjects studied, continued treatmentwith metronidazole gel alone maintains remission of moderate to severe rosacea induced by treatment with Oral tetracycline and topical metronidazole gel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 05:57:34