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Titolo:
STIMULATION OF NTS ACTIVATES NMDA AND NON-NMDA RECEPTORS IN RAT CARDIAC VAGAL NEURONS IN THE NUCLEUS AMBIGUUS
Autore:
NEFF RA; MIHALEVICH M; MENDELOWITZ D;
Indirizzi:
UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS,894 UNION AVE MEMPHIS TN 38163 UNIV TENNESSEE,CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS MEMPHIS TN 38163
Titolo Testata:
Brain research
fascicolo: 2, volume: 792, anno: 1998,
pagine: 277 - 282
SICI:
0006-8993(1998)792:2<277:SONANA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; BRAIN-STEM; PROJECTIONS; MOTONEURONS; CURRENTS; MEDULLA; CAT;
Keywords:
PARASYMPATHETIC; CARDIOVASCULAR; NUCLEUS TRACTUS SOLITARIUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Neff et al., "STIMULATION OF NTS ACTIVATES NMDA AND NON-NMDA RECEPTORS IN RAT CARDIAC VAGAL NEURONS IN THE NUCLEUS AMBIGUUS", Brain research, 792(2), 1998, pp. 277-282

Abstract

While it is widely accepted that tonic and reflex changes in cardiac vagal activity play significant roles in cardiovascular function, little is known about the synaptic pathways in the brainstem responsible for the control of cardiac vagal neurons in the nucleus ambiguus (NA). In this study, we identified the principal post-synaptic receptors activated in cardiac vagal neurons upon stimulation of the nucleus tractus solitarius (NTS). Cardiac vagal neurons were identified by the presence of a retrograde fluorescent tracer and were visualized in rat brainstem slices. Perforated patch clamp techniques were used to record post-synaptic currents. NTS stimulation activated glutamatergic currentsin cardiac vagal neurons with a typical delay of 8-18 ms. Post-synaptic responses were separated into NMDA and non-NMDA components using D-2-amino-5-phophonovalerate (AP5) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), respectively. In conclusion, this study characterizes a monosynaptic glutamatergic pathway from NTS that activates NMDA and kainate/AMPA post-synaptic receptors in cardiac vagal neurons. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:31:38