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Titolo:
VENOMS, ANTIVENOMS AND IMMUNOTHERAPY
Autore:
CHIPPAUX JP; GOYFFON M;
Indirizzi:
MUSEUM NATL HIST NAT,LERAI,57 RUE CUVIER F-75005 PARIS FRANCE MUSEUM NATL HIST NAT,LERAI F-75005 PARIS FRANCE CERMES,DR ORSTOM NIAMEY NIGER
Titolo Testata:
Toxicon
fascicolo: 6, volume: 36, anno: 1998,
pagine: 823 - 846
SICI:
0041-0101(1998)36:6<823:VAAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DURISSUS-TERRIFICUS VENOM; IMMUNOSORBENT-ASSAY ELISA; RANDOMIZED COMPARATIVE TRIAL; MALAYAN PIT VIPER; SNAKE-VENOM; POLYVALENT ANTIVENOM; RATTLESNAKE VENOM; FAB FRAGMENTS; CALLOSELASMA-RHODOSTOMA; MONOCLONAL-ANTIBODY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
165
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Chippaux e M. Goyffon, "VENOMS, ANTIVENOMS AND IMMUNOTHERAPY", Toxicon, 36(6), 1998, pp. 823-846

Abstract

A century after the discovery of antivenom and despite real progress undertaken in its manufacture, its use remains largely empirical. Recent studies of pharmacokinetics of envenoming permitted improved understanding of immunotherapy. Improved purification of the antivenom by using immunoglobulin fragments has lead to increased tolerance and efficiency of antivenom. The respective advantages and disadvantages of F(ab')(2) and F(ab) are discussed in relation to neutralising efficacy and clearance from the circulation. Although the time during which the action of antivenom remains beneficial after the bite is unknown, the superiority of intravenous administration has now been proved, Althoughimmunisation procedures and purification and use of IgG fragments call be improved using modern technology, the future of immunotherapy seems promising. It is vital that therapeutic protocols should be rigidlyadhered to in order to optimise immunotherapy. The use of vaccinationhas yet to be explored. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:28:51