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Titolo:
ASSESSMENT OF SPONTANEOUS FLUCTUATIONS OF VIRAL LOAD IN UNTREATED PATIENTS WITH CHRONIC HEPATITIS-C BY 2 STANDARDIZED QUANTITATION METHODS - BRANCHED DNA AND AMPLICOR MONITOR
Autore:
HALFON P; BOURLIERE M; HALIMI G; KHIRI H; BERTEZENE P; PORTAL I; BOTAFRIDLUND D; GAUTHIER AP; JULLIEN M; FERYN JM; GEROLAMI V; CARTOUZOU G;
Indirizzi:
HOP AMBROISE PARE,LAB ALPHABIO,23 RUE FRIEDLAND F-13006 MARSEILLE FRANCE HOP CONCEPTION,ALPHABIO LAB MARSEILLE FRANCE HOP CONCEPTION,DEPT BIOCHEM MARSEILLE FRANCE HOP CONCEPTION,DEPT HEPATOGASTROENTEROL MARSEILLE FRANCE HOP ST JOSEPH,DEPT HEPATOGASTROENTEROL MARSEILLE FRANCE INSERM,U315 F-13258 MARSEILLE FRANCE
Titolo Testata:
Journal of clinical microbiology
fascicolo: 7, volume: 36, anno: 1998,
pagine: 2073 - 2075
SICI:
0095-1137(1998)36:7<2073:AOSFOV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-ALFA THERAPY; VIRUS-RNA; HCV RNA; INFECTION; TURNOVER; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
P. Halfon et al., "ASSESSMENT OF SPONTANEOUS FLUCTUATIONS OF VIRAL LOAD IN UNTREATED PATIENTS WITH CHRONIC HEPATITIS-C BY 2 STANDARDIZED QUANTITATION METHODS - BRANCHED DNA AND AMPLICOR MONITOR", Journal of clinical microbiology, 36(7), 1998, pp. 2073-2075

Abstract

Quantitation of hepatitis C virus (HCV) RNA in serum has been used topredict and monitor the efficacy of interferon therapy in chronic HCVinfection. We prospectively studied the fluctuation of viremia by a longitudinal follow-up of HCV RNA levels for 2 months in six untreated patients. Spontaneous fluctuations of HCV RNA ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9- to 5.6-fold with Monitor. These large spontaneous fluctuations (up to 0.75 log), observed daily, weekly, and monthly, raise doubt about the clinical value of a single assessment of pretherapeutic viremia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:38:07