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Titolo:
AURINTRICARBOXYLIC ACID PREVENTS GLUR2 MESSENGER-RNA DOWN-REGULATION AND DELAYED NEURODEGENERATION IN HIPPOCAMPAL CA1 NEURONS OF GERBIL AFTER GLOBALISCHEMIA
Autore:
ARONICA EM; GORTER JA; GROOMS S; KESSLER JA; BENNETT MVL; ZUKIN RS; ROSENBAUM DM;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL BRONX NY 10461
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 12, volume: 95, anno: 1998,
pagine: 7115 - 7120
SICI:
0027-8424(1998)95:12<7115:AAPGMD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; RECEPTOR GENE-EXPRESSION; RAT HIPPOCAMPUS; GLOBAL-ISCHEMIA; NMDA RECEPTOR; SYMPATHETIC NEURONS; CEREBRAL-ISCHEMIA; BRAIN ISCHEMIA; SPIDER TOXIN; ADULT-RATS;
Keywords:
TRANSIENT ISCHEMIA; DEGENERATION; AMPA RECEPTORS; GLUR2; MESSENGER-RNA EXPRESSION; EXCITOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Aronica et al., "AURINTRICARBOXYLIC ACID PREVENTS GLUR2 MESSENGER-RNA DOWN-REGULATION AND DELAYED NEURODEGENERATION IN HIPPOCAMPAL CA1 NEURONS OF GERBIL AFTER GLOBALISCHEMIA", Proceedings of the National Academy of Sciences of the United Statesof America, 95(12), 1998, pp. 7115-7120

Abstract

Aurintricarboxylic acid (ATA), an inhibitor of endonuclease activity and other protein-nucleic acid interactions, blocks apoptosis in several cell types and prevents delayed death of hippocampal pyramidal CA1 neurons induced by transient global ischemia, Global ischemia in rats and gerbils induces down-regulation of GluR2 mRNA and increased lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced Ca2+ influx in CA1 before neurodegeneration, This result and neuroprotection by antagonists of AMPA receptors suggests that formation of AMPA receptors lacking GluR2, and therefore Ca2+ permeable, leads to excessiveCa2+ influx in response to endogenous glutamate; the resulting delayed neuronal death in CA1 exhibits many characteristics of apoptosis, Inthis study, we examined the effects of ATA on expression of mRNAs encoding glutamate receptor subunits in gerbil hippocampus after global ischemia, Administration of ATA by injection into the right cerebral ventricle 1 h before (but not 6 h after) bilateral carotid occlusion prevented the ischemia-induced decrease in GluR2 mRNA expression and the delayed neurodegeneration, These findings suggest that ATA is neuroprotective in ischemia by blocking the transcriptional changes leading todown-regulation of GluR2, rather than by simply blocking endonucleases, which presumably act later after Ca2+ influx initiates apoptosis, Maintaining formation of Ca2+ impermeable, GluR2 containing AMPA receptors could prevent delayed death of CA1 neurons after transient global ischemia, and block of GluR2, down-regulation may provide a further strategy for neuroprotection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:28:30