Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTRACORONARY INFUSION OF REDUCED GLUTATHIONE IMPROVES ENDOTHELIAL VASOMOTOR RESPONSE TO ACETYLCHOLINE IN HUMAN CORONARY CIRCULATION
Autore:
KUGIYAMA K; OHGUSHI M; MOTOYAMA T; HIRASHIMA O; SOEJIMA H; MISUMI K; YOSHIMURA M; OGAWA H; SUGIYAMA S; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,HONJO 1-1-1 KUMAMOTO 860 JAPAN
Titolo Testata:
Circulation
fascicolo: 23, volume: 97, anno: 1998,
pagine: 2299 - 2301
SICI:
0009-7322(1998)97:23<2299:IIORGI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; CELLS; ESTER;
Keywords:
ANTIOXIDANTS; FREE RADICALS; ENDOTHELIUM-DERIVED FACTORS; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
K. Kugiyama et al., "INTRACORONARY INFUSION OF REDUCED GLUTATHIONE IMPROVES ENDOTHELIAL VASOMOTOR RESPONSE TO ACETYLCHOLINE IN HUMAN CORONARY CIRCULATION", Circulation, 97(23), 1998, pp. 2299-2301

Abstract

Background-Oxygen free radicals have been shown to cause endothelial vasomotor dysfunction, This study examined the effect of reduced glutathione (GSH), an antioxidant, on human coronary circulation, Methods and Results-Responses of epicardial diameter and blood flow of the leftanterior descending coronary artery to intracoronary infusion of acetylcholine (ACh, 50 mu g/min) were measured by quantitative coronary angiography and Doppler flow-wire technique, respectively, before and during combined intracoronary infusion of GSH (50 mg/min) or saline in 26 subjects with no significant coronary stenosis. GSH infusion suppressed the constrictor response of epicardial diameter to ACh and enhanced the increase in blood flow response to ACh, Furthermore, GSH potentiated the coronary dilator effect of nitroglycerin. A beneficial effectof GSH on the epicardial diameter response to ACh was observed in a subgroup of subjects with greater than or equal to 1 coronary risk factors but not in a subgroup without risk factors. Saline infusion did not have any effects. Conclusions-The results indicate that GSH improvedcoronary endothelial vasomotor function, particularly in subjects with coronary risk factors, and it potentiated the vasodilator effect of nitroglycerin in human coronary arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:55:52