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Titolo:
THROMBIN INDUCES THE ASSOCIATION OF CYCLIC ADP-RIBOSE-SYNTHESIZING CD38 WITH THE PLATELET CYTOSKELETON
Autore:
TORTI M; FESTETICS ET; BERTONI A; SINIGAGLIA F; BALDUINI C;
Indirizzi:
UNIV PAVIA,DEPT BIOCHEM,VIA BASSI 21 I-27100 PAVIA ITALY UNIV GENOA,INST BIOL CHEM I-16132 GENOA ITALY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 428, anno: 1998,
pagine: 200 - 204
SICI:
0014-5793(1998)428:3<200:TITAOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE ANTIGEN CD38; TYROSINE PHOSPHORYLATION; PHOSPHOLIPASE-C; CELL ACTIVATION; MOLECULE; KINASE; AGGREGATION; MEMBRANE; EXPRESSION; APOPTOSIS;
Keywords:
ADP-RIBOSYL CYCLASE; CD38; CYTOSKELETON; PLATELET; INTEGRIN-ALPHA(IIB)BETA(3);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Torti et al., "THROMBIN INDUCES THE ASSOCIATION OF CYCLIC ADP-RIBOSE-SYNTHESIZING CD38 WITH THE PLATELET CYTOSKELETON", FEBS letters, 428(3), 1998, pp. 200-204

Abstract

The effect of platelet stimulation on the subcellular localization ofCD38, a membrane glycoprotein that catalyses the synthesis of cyclic ADP-ribose from beta-NAD(+) was investigated: Treatment of human platelets with thrombin caused the association of about 40% of the total ADP-ribosyl cyclase activity with the cytoskeleton, through the translocation of the CD38 molecule from the Triton S-100-soluble to the insoluble fraction. The interaction of CD38 with the cytoskeleton was a specific and reversible process? mediated by the binding to the actin-richfilaments and was inhibited by treatment of platelets with cytochalasin D. This event was regulated by integrin alpha(IIb)beta(3) and platelet aggregation as it was prevented by the inhibition of fibrinogen binding and was not observed in platelets from a patient affected by Glanzmann thrombasthenia, These results demonstrate that the subcellular localization of CD38 can be influenced by platelet stimulation with physiological agonists, and that membrane CD38 can interact with intracellular proteins. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:22:23