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Titolo:
EFFECTS OF FLUOXETINE ON THE DEVELOPMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS
Autore:
FREIREGARABAL M; NUNEZ MJ; PEREIRO D; RIVEIRO P; LOSADA C; FERNANDEZRIAL JC; GARCIAIGLESIAS E; PRIZMIC J; MAYAN JM; REYMENDEZ M;
Indirizzi:
UNIV SANTIAGO DE COMPOSTELA,FAC FARM,DEPT FARMACOL,CAMPUS SUR SANTIAGO COMPOSTE 15705 SPAIN UNIV SANTIAGO DE COMPOSTELA,DEPT NURSING SANTIAGO COMPOSTE 15705 SPAIN UNIV SANTIAGO DE COMPOSTELA,DEPT PSYCHOBIOL SANTIAGO COMPOSTE 15705 SPAIN UNIV SANTIAGO DE COMPOSTELA,DEPT BIOCHEM SANTIAGO COMPOSTE 15705 SPAIN UNIV JF KENNEDY BUENOS AIRES DF ARGENTINA
Titolo Testata:
Life sciences
fascicolo: 2, volume: 63, anno: 1998,
pagine: 31 - 38
SICI:
0024-3205(1998)63:2<31:EOFOTD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; KILLER-CELL CYTOTOXICITY; IMMUNE-RESPONSE; UPTAKE INHIBITORS; RESTRAINT STRESS; SEROTONIN UPTAKE; SURGICAL STRESS; TUMOR-GROWTH; MICE; PROMOTE;
Keywords:
FLUOXETINE; SURGERY; STRESS; CANCER; WALKER RAT CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M. Freiregarabal et al., "EFFECTS OF FLUOXETINE ON THE DEVELOPMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS", Life sciences, 63(2), 1998, pp. 31-38

Abstract

Experiments were performed in order to evaluate the effects of fluoxetine, a selective inhibitor of neural serotonin transporter antidepressant, on the development lung metastases in rats subjected to laparotomy and injected (i.v.) with 10(4) Walker 256 (W-256) carcinosarcoma cells. The number of metastatic nodules on the surface of the lungs, as well as the percentage area of metastases in the frontal section through pulmonary hilus were increased in rats subjected to sham-surgery orlaparotomy. Treatment with fluoxetine (5 mg/kg) partially reversed those adverse effects of surgery, but the difference was clearer when itwas administered before surgery was performed. Survival periods were also assessed and fluoxetine was found to decrease the lethality of rats exposed to surgery. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:15:13