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Titolo:
VARIATION IN THE PROREGION STRUCTURE OF HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR PRECURSORS
Autore:
LOUKIANOV EV; LOUKIANOVA T; WIEDLOCHA A; OLSNES S;
Indirizzi:
NORWEGIAN RADIUM HOSP,INST CANC RES,DEPT BIOCHEM OSLO NORWAY NORWEGIAN RADIUM HOSP,INST CANC RES,DEPT BIOCHEM OSLO NORWAY
Titolo Testata:
Gene
fascicolo: 1, volume: 212, anno: 1998,
pagine: 1 - 4
SICI:
0378-1119(1998)212:1<1:VITPSO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIPHTHERIA-TOXIN RECEPTOR; AMPHIREGULIN; EXPRESSION; ORGANIZATION; PROTEIN;
Keywords:
HB-EGF; GROWTH FACTOR PRECURSOR; SPLICING VARIANTS; PROREGION; HEPARIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
E.V. Loukianov et al., "VARIATION IN THE PROREGION STRUCTURE OF HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR PRECURSORS", Gene, 212(1), 1998, pp. 1-4

Abstract

In a previous study, we have isolated and characterized cDNA encodinga novel 'short form' of heparin-binding EGF-like growth factor (SF HB-EGF) (Loukianov et al., 1997). In the present work, we have found that cDNA for SF HB-EGF and for full-length HB-EGF are each represented by two variants, which we refer to as L and P forms. The L form is the previously known form of HB-EGF cDNA and encodes a leucine in position33. The P form described in this report, encodes a proline in codon 33. The L33P substitution is predicted to cause a significant alteration in the proregion structure of SF HB-EGF and HB-EGF. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:49:34