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Titolo:
THE D-2 DOPAMINE-RECEPTOR GENE - A REVIEW OF ASSOCIATION STUDIES IN ALCOHOLISM AND PHENOTYPES
Autore:
NOBLE EP;
Indirizzi:
UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT,DEPT PSYCHIAT,ALCOHOL RES CTR,760 WESTWOOD PLAZA LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90024
Titolo Testata:
Alcohol
fascicolo: 1, volume: 16, anno: 1998,
pagine: 33 - 45
SICI:
0741-8329(1998)16:1<33:TDDG-A>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; ANGIOTENSIN-CONVERTING-ENZYME; D2 RECEPTOR; ALLELIC ASSOCIATION; NUCLEUS-ACCUMBENS; A1 ALLELE; NOVELTY SEEKING; RISK FACTOR; DELETION POLYMORPHISM; POLYSUBSTANCE ABUSERS;
Keywords:
DRD2 GENE; DOPAMINE; ALCOHOLISM; DRUG ABUSE; ASSOCIATION STUDIES; PHENOTYPES; TAQI A ALLELES; D-2 DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
119
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Noble, "THE D-2 DOPAMINE-RECEPTOR GENE - A REVIEW OF ASSOCIATION STUDIES IN ALCOHOLISM AND PHENOTYPES", Alcohol, 16(1), 1998, pp. 33-45

Abstract

The role of the D-2 dopamine receptor (DRD2) gene in alcoholism and other substance use disorders has come under intense investigation since the minor TaqI A (Al) allele of the DRD2 gene was first reported to be associated with alcoholism. In a meta-analysis of 15 US and international studies of European (non-Hispanic) Caucasians, consisting of 1015 alcoholics (more severe and less severe) and 898 controls (unassessed and assessed for alcoholism), alcoholics had a higher prevalence (p< 10(-7), and frequency (p < 10(-5)) of the Al allele than controls. The prevalence of the Al allele was 1.5-fold higher in more severe than less severe alcoholics (p < 10(-4)), whereas unassessed controls hada twofold higher prevalence of the Al allele than assessed controls (p < 10(-4)). Whereas more severe alcoholics had a threefold higher Al allelic prevalence than assessed controls (p < 10(-10)), Al allelic prevalence was virtually identical in less severe alcoholics and in unassessed controls. The Al allele has also been associated with other drug problems including cocaine, nicotine, and polysubstance abuse. Furthermore, the minor TaqI B (B1) allele of the DRD2 gene has been associated with alcoholism and psychostimulant (cocaine, amphetamine) abuse. Beyond association studies, phenotypic differences exist between genotypes containing the TaqI A minor (A1A1 and A1A2) and major (A2A2) alleles of the DRD2. These different phenotypes have been identified through a number of approaches, including pharmacological, neurophysiological, neuropsychological, stress, personality, metabolic, and treatment studies. In conclusion, the present review suggests that the type of alcoholics and the nature of controls used are among critical factors in DRD2 association studies in alcoholism. Intronic mutations in both the 3'(TaqI A) and 5'(TaqI B) regions of the DRD2 associate with alcoholism and other drug use disorders. The identification of phenotypes ofDRD2 genotypes suggests that the observed intronic DRD2 mutations mayhave functional consequences that predispose individuals to a varietyof substance use disorders. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:12:39