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Titolo:
ANDROGEN ACTION DURING MALE SEX-DIFFERENTIATION INCLUDES SUPPRESSION OF CRANIAL SUSPENSORY LIGAMENT DEVELOPMENT
Autore:
EMMEN JMA; MCLUSKEY A; GOOTEGOED JA; BRINKMANN AO;
Indirizzi:
ERASMUS UNIV,FAC MED & HLTH SCI,DEPT ENDOCRINOL & REPROD,POB 1738 NL-3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Human reproduction
fascicolo: 5, volume: 13, anno: 1998,
pagine: 1272 - 1280
SICI:
0268-1161(1998)13:5<1272:AADMSI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MAMMARY-GLAND; TESTICULAR DESCENT; UROGENITAL TRACT; GROWTH-FACTORS; WOLFFIAN DUCT; CELL-DEATH; RAT; CRYPTORCHIDISM; GUBERNACULUM; RECEPTOR;
Keywords:
ANDROGEN; GENITAL SYSTEM; SEX DIFFERENTIATION; TESTIS DESCENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.M.A. Emmen et al., "ANDROGEN ACTION DURING MALE SEX-DIFFERENTIATION INCLUDES SUPPRESSION OF CRANIAL SUSPENSORY LIGAMENT DEVELOPMENT", Human reproduction, 13(5), 1998, pp. 1272-1280

Abstract

The cranial suspensory ligament is located on the border of the cranial (mesonephric) mesentery in adult female mammals, which runs betweenthe cranial pole of the internal genitalia and the dorsal abdominal wall. Absence of the cranial suspensory ligament in male mammals depends upon exposure of its primordium to fetal testicular androgens and isa prerequisite for testis descent. Female rats were exposed to 5 alpha-dihydrotestosterone propionate at different stages of genital development, and cranial suspensory ligament development was studied in neonatal and in adult animals, Androgens suppressed cranial suspensory ligament development when exposure started during the early stages of genital development, until day 19 postconception (pc), Androgen receptor expression was immunohistochemically detected in the cranial mesenteryof both sexes from day 16 pc onwards. A decrease of androgen receptorexpression in female fetuses from day 18 pc onwards coincided with the appearance of a differentiated cranial suspensory ligament, as evidenced by the expression of two cell differentiation markers: a-smooth muscle (alpha-SM) actin and desmin, alpha-SM actin was located on the outer border of the cranial mesentery of both sexes at day 17 pc, and expression increased only in female fetuses, On day 19 pc, desmin expression was also detectable in the alpha-SM actin-positive cells. Proliferation and apoptosis indices of cells in the cranial mesentery, as analysed by 5'-bromodeoxyuridine incorporation and by detection of DNA strand breaks (TUNEL method) respectively, did not show any difference between the sexes, neither on day 17 nor on day 18 pc. Since primordial cells of the cranial suspensory ligament highly express the androgenreceptor during the period of gestation when androgens can suppress cranial suspensory development, altered morphogenesis of these cells may be a direct consequence of androgen action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:10:51