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Titolo:
INTERACTION OF MODAFINIL AND CLOMIPRAMINE AS COMEDICATION IN A NARCOLEPTIC PATIENT
Autore:
GROZINGER M; HARTTER S; HIEMKE C; GRIESE EU; ROSCHKE J;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55101 MAINZ GERMANY DR MARGARETE FISCHER BOSCH INST CLIN PHARMACOL D-7000 STUTTGART GERMANY
Titolo Testata:
Clinical neuropharmacology
fascicolo: 2, volume: 21, anno: 1998,
pagine: 127 - 129
SICI:
0362-5664(1998)21:2<127:IOMACA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Keywords:
MODAFINIL; CLOMIPRAMINE; DRUG INTERACTION; NARCOLEPSY; HYPERSOMNIA; CYTOCHROME P450 ISOENZYME;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
M. Grozinger et al., "INTERACTION OF MODAFINIL AND CLOMIPRAMINE AS COMEDICATION IN A NARCOLEPTIC PATIENT", Clinical neuropharmacology, 21(2), 1998, pp. 127-129

Abstract

Modafinil is a psychostimulant compound that is just now becoming available in many countries for treatment of narcoleptic and hypersomnic patients. Whereas sleep attacks and drowsiness can be effectively improved, the drug does not sufficiently reduce cataplectic seizures. It therefore is often used in combination with tricyclic antidepressant medication, although little is known about the possible interactions. This case report describes a narcoleptic patient chronically treated with clomipramine who started receiving modafinil. The blood concentrations of clomipramine and its metabolite showed a significant dose-dependent and reversible increase under modafinil. Since the patient was genotypically and phenotypically a cytochrome P450 2D6 poor metabolizer, the authors attribute the relevant pharmacokinetic interaction to another clomipramine-metabolizing enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:15:56