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Titolo:
INTERACTIONS OF KETOPROFEN AND IBUPROFEN WITH BETA-CYCLODEXTRINS IN SOLUTION AND IN THE SOLID-STATE
Autore:
MURA P; BETTINETTI GP; MANDERIOLI A; FAUCCI MT; BRAMANTI G; SORRENTI M;
Indirizzi:
UNIV FLORENCE,DIPARTIMENTO SCI FARMACEUT,VIA G CAPPONI 9 I-50121 FLORENCE ITALY UNIV PAVIA,DIPARTIMENTO CHIM FARMACEUT I-27100 PAVIA ITALY
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 166, anno: 1998,
pagine: 189 - 203
SICI:
0378-5173(1998)166:2<189:IOKAIW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; INCLUSION COMPLEXES; GAMMA-CYCLODEXTRIN; DISSOLUTION; FLURBIPROFEN; NAPROXEN; DRUGS; RATS;
Keywords:
IBUPROFEN; KETOPROFEN; CHEMICALLY MODIFIED BETA-CYCLODEXTRINS; INCLUSION COMPLEXATION; PHASE-SOLUBILITY ANALYSIS; C-13 NMR; IR SPECTROSCOPY; DIFFERENTIAL SCANNING CALORIMETRY; X-RAY DIFFRACTOMETRY; DISSOLUTION RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Mura et al., "INTERACTIONS OF KETOPROFEN AND IBUPROFEN WITH BETA-CYCLODEXTRINS IN SOLUTION AND IN THE SOLID-STATE", International journal of pharmaceutics, 166(2), 1998, pp. 189-203

Abstract

The complexing, solubilizing and amorphizing abilities towards ketoprofen and ibuprofen of native beta-cyclodextrin and some randomly substituted amorphous derivatives (methyl, hydroxyethyl, and hydroxypropyl beta-cyclodextrin with an average substitution degree per anhydroglucose unit, respectively of 1.8, 1.6 and 0.9) were determined and compared with those already observed for naproxen. Drug-carrier interactions were studied in aqueous solution by means of phase-solubility analysisand C-13 NMR spectroscopy, and in the solid state using differential scanning calorimetry (DSC), X-ray powder diffractometry and infrared spectroscopy. The strength of the inclusion complexes with beta-cyclodextrins (K-1:1,K-ibu, K-1:1,K-nap > K-1:1,K-keto) was directly related to the hydrophobic character of the guest (log P values) and depended on its molecular features. The presence in physical mixtures of a high-energy state of crystalline drug molecularly dispersed in the amorphous carrier was assumed from DSC, behaviour. Dissolution rates (dispersed amount method) of the active ingredient from equimolar drug-cyclodextrin physical mixtures and amorphous colyophilized products showed that methyl beta-cyclodextrin was the most effective carrier also for ketoprofen and ibuprofen. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:19:00