Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SPECT IMAGING OF ODOR IDENTIFICATION IN SCHIZOPHRENIA
Autore:
MALASPINA D; PERERA GM; LIGNELLI A; MARSHALL RS; ESSER PD; STORER S; FURMAN V; WRAY AD; COLEMAN E; GORMAN JM; VANHEERTUM RL;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,722 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIOL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH MED NEW YORK NY 10032
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 82, anno: 1998,
pagine: 53 - 61
SICI:
0925-4927(1998)82:1<53:SIOOII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; TEMPORAL-LOBE LESIONS; OLFACTORY DEFICITS; CORTEX; MEMORY; DISCRIMINATION; DYSFUNCTION; HIPPOCAMPUS; DISEASE; MONKEY;
Keywords:
UPSIT; OLFACTION; FUNCTIONAL BRAIN IMAGING; HIPPOCAMPUS; PICTURE-MATCHING; FUSIFORM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D. Malaspina et al., "SPECT IMAGING OF ODOR IDENTIFICATION IN SCHIZOPHRENIA", PSYCHIATRY RESEARCH-NEUROIMAGING, 82(1), 1998, pp. 53-61

Abstract

Deficits in olfactory identification, despite normal odor perception,are found in some neuropsychiatric disorders, including schizophrenia. We examined if regional cerebral blood flow (rCBF) differed between schizophrenia patients and controls during odor identification, hypothesizing that these brain regions could be relevant to odor identification impairments. Eight schizophrenia and eight comparison subjects provided a baseline (picture identity matching) and activation (odor identification) SPECT scan, obtained using Tc-99m-HMPAO in a low dose/highdose design. Six patients and seven controls had analyzable data. MEDX data saved in ANALYZE format for SPM 95 generated paired t-test statistical data for display in Talairach space, with rCBF changes given as Z-scores. There was no schizophrenia vs. control group difference inrCBF for the baseline picture-matching test. For odor identification,schizophrenia patients had a hypometabolic right-sided cortical region that included the frontal lobe Broca's area, superior temporal lobe,and supramarginal and angular gyri. Post hoc within-group contrasts of picture-matching vs. odor identification showed that the controls significantly increased rCRF in the right-sided inferior temporal fusiform gyrus, and bilateral hippocampi and visual association areas for the odor test. The schizophrenia group showed no rCBF differences for picture-matching compared to odor identification. Patients showed significant hypometabolism in right-sided cortical areas for odor identification. They also failed to show increased rCBF in the hippocampus and visual association area, as seen in controls for odor identification compared to picture-matching. These regions may be unique to schizophrenia or have broader implications for olfactory memory retrieval. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 05:54:41