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Titolo:
PROTON EJECTION AS A MAJOR FEATURE OF THE CA2-PUMP()
Autore:
DACOSTA AG; MADEIRA VMC;
Indirizzi:
CTR BIOL CELULAR P-3049 COIMBRA PORTUGAL DEPT BIOQUIM P-3049 COIMBRA PORTUGAL
Titolo Testata:
Biochimica et biophysica acta. Biomembranes
fascicolo: 2, volume: 1189, anno: 1994,
pagine: 181 - 188
SICI:
0005-2736(1994)1189:2<181:PEAAMF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOPLASMIC-RETICULUM CA-2+-ATPASE; ADENOSINE-TRIPHOSPHATASE; CALCIUM-TRANSPORT; ATP HYDROLYSIS; PUMP PROTEIN; CA-ATPASE; CATALYTIC SITE; CA-2+; CA2+-ATPASE; VESICLES;
Keywords:
CALCIUM PUMP; PROTON EJECTION; SARCOPLASMIC RETICULUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Dacosta e V.M.C. Madeira, "PROTON EJECTION AS A MAJOR FEATURE OF THE CA2-PUMP()", Biochimica et biophysica acta. Biomembranes, 1189(2), 1994, pp. 181-188

Abstract

H+ ejection and Ca2+ uptake promoted by the sarcoplasmic reticulum (SR) Ca2+-pump are similarly stimulated by millimolar Mg2+. This cannot be assigned to enhanced Ca2+ uptake and H+ displacement from internal metal binding sites since: (1) loading SR vesicles with high Mg2+ concentrations does not impair H+ ejection; (2) loading SR vesicles with Mn2+ does not depress H+ ejection occurring during Mn2+ uptake; (3) H+ ejection occurs even when Ca2+ accumulation inside the vesicles is prevented with Ca2+ ionophores. It is concluded that the Ca2+-pump promotes an active Ca2+/H+ countertransport stimulated by Mg2+. Finally, a mechanism for Ca2+ translocation is proposed in basic physico-chemical terms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:37:39