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Titolo:
MODELING OF PREPARATIVE LIQUID-CHROMATOGRAPHY
Autore:
GOLSHANSHIRAZI S; GUIOCHON G;
Indirizzi:
UNIV TENNESSEE,DEPT CHEM KNOXVILLE TN 37996 UNIV TENNESSEE,DEPT CHEM KNOXVILLE TN 37996 OAK RIDGE NATL LAB,DIV ANALYT CHEM OAK RIDGE TN 37831
Titolo Testata:
Journal of chromatography
fascicolo: 2, volume: 658, anno: 1994,
pagine: 149 - 171
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVERLOADED ELUTION CHROMATOGRAPHY; COMPETITIVE ADSORPTION-ISOTHERMS; LARGE CONCENTRATION BANDS; IDEAL MODEL; NONLINEAR CHROMATOGRAPHY; LANGMUIR ISOTHERM; BINARY MIXTURE; SYSTEM PEAKS; PROFILES; PREDICTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
S. Golshanshirazi e G. Guiochon, "MODELING OF PREPARATIVE LIQUID-CHROMATOGRAPHY", Journal of chromatography, 658(2), 1994, pp. 149-171

Abstract

In order to achieve an acceptable production rate at reasonable cost,preparative chromatography must be carried out with phase systems in which the kinetics of mass transfers and adsorption-desorption are fast. Accordingly, band profiles in overloaded chromatographic columns are best understood by considering the ideal model, while the process itself is most suitably modeled using the equilibrium-dispersive model. The former model assumes an infinite column efficiency, while the latter lumps the contributions of axial dispersion and mass transfer resistances into a single apparent dispersion coefficient. The properties and solutions of these models are reviewed. The conditions under which they give satisfactory results are summarized. The excellent agreementbetween the experimental band profiles of the components of binary mixtures and the individual band profiles calculated with the equilibrium-dispersive model is demonstrated. The degree of agreement is limitedonly by the accuracy with which the competitive equilibrium isothermsare accounted for.

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Documento generato il 09/07/20 alle ore 01:03:09