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Titolo:
DIFFERENTIAL EFFECT OF SELECTIVE CYCLOOXYGENASE-2 (COX-2) INHIBITOR NS-398 AND DICLOFENAC ON FORMALIN-INDUCED NOCICEPTION IN THE RAT
Autore:
EUCHENHOFER C; MAIHOFNER C; BRUNE K; TEGEDER I; GEISSLINGER G;
Indirizzi:
UNIV ERLANGEN NURNBERG,DEPT EXPT & CLIN PHARMACOL & TOXICOL,UNIV STR 22 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT EXPT & CLIN PHARMACOL & TOXICOL D-91054 ERLANGEN GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 248, anno: 1998,
pagine: 25 - 28
SICI:
0304-3940(1998)248:1<25:DEOSC(>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-G/H SYNTHASE; MESSENGER-RNA; INFLAMMATION; NS-398; BRAIN; TIS10;
Keywords:
NS-398; DICLOFENAC; RAT FORMALIN TEST; ANTINOCICEPTION; CYCLOOXYGENASE-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C. Euchenhofer et al., "DIFFERENTIAL EFFECT OF SELECTIVE CYCLOOXYGENASE-2 (COX-2) INHIBITOR NS-398 AND DICLOFENAC ON FORMALIN-INDUCED NOCICEPTION IN THE RAT", Neuroscience letters, 248(1), 1998, pp. 25-28

Abstract

Prostaglandins (PGs) are known to be involved in inflammatory and nociceptive processing. Since the discovery of at least two isozymes of cyclooxygenase (COX), inhibition of COX-2 has been suggested to be responsible for the therapeutic effects of nonsteroidal anti-inflammatory drugs (NSAIDs). In the present study, the effects of a rather selective COX-2 inhibitor, NS-398 (0.3-27 mg/kg i.p.), were studied using the rat formalin test as a model of acute nociception. Diclofenac (non-selective COX inhibitor; 0.3-27 mg/kg i.p.) was used as a control. NS-398revealed antinociceptive activity only at a dose (27 mg/kg) which results in plasma concentrations which most likely do not selectively inhibit COX-2. By contrast, diclofenac inhibited formalin-induced flinching behaviour over the whole dose range tested. Our results suggest that PGs mediating nociception in the formalin test of the rat are most likely produced via the COX-1 as well as COX-2 pathways. Thus, in an acute model of nociception a nonselective COX inhibitor may offer advantages as compared to a selective COX-2 inhibitor. (C) 1998 Elsevier Science Ireland Ltd.

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Documento generato il 03/07/20 alle ore 01:27:28