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Titolo:
RELATIVE CONTRIBUTION OF CALORIES FROM DIETARY-FAT, CARBOHYDRATE, ANDFIBER IN THE PROMOTION OF DMBA-INDUCED MAMMARY-TUMORS IN SPRAGUE-DAWLEY RATS
Autore:
JACKSON CD; WEIS C; CHEN JJ; BECHTEL DH; POIRIER LA;
Indirizzi:
US FDA,NATL CTR TOXICOL RES,3900 NCTR RD JEFFERSON AR 72079 BEST FOODS SOMERSET NJ 08873
Titolo Testata:
Nutrition and cancer
fascicolo: 3, volume: 30, anno: 1998,
pagine: 194 - 200
SICI:
0163-5581(1998)30:3<194:RCOCFD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; BODY-WEIGHT; CARCINOGENESIS; TUMORIGENESIS; RESTRICTION; PREVENTION; PROTEIN; ENERGY; GROWTH; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Jackson et al., "RELATIVE CONTRIBUTION OF CALORIES FROM DIETARY-FAT, CARBOHYDRATE, ANDFIBER IN THE PROMOTION OF DMBA-INDUCED MAMMARY-TUMORS IN SPRAGUE-DAWLEY RATS", Nutrition and cancer, 30(3), 1998, pp. 194-200

Abstract

It is well known that caloric restriction inhibits, whereas excess calories promote, mammary tumorigenesis in rats. However, the relative contributions to carcinogenesis by calories derived from fat or from carbohydrate are not well established. To determine the relative effectsof calories from fat or from carbohydrate, as well as any interactionof dietary fiber on the promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumors, we fed isocalorically nine diets containing different ratios of fat, carbohydrate, and fiber to female Sprague-Dawleyrats treated with 7,12-dimethylbenz[a]anthracene (30/group). Under conditions of isocaloric consumption, at or near ad libitum feeding, calories from dietary fat had approximately twofold greater promoting effect on final body weight and tumor incidence than calories derived from dietary carbohydrate. Dietary fiber had an inhibitory effect on tumor development, but the effect was evident only in the high-fat groups. Logistic regression analysis of tumor incidence gave beta-coefficientestimates for the relative effects of fat, carbohydrate, and fiber of0.866, 0.189, and -4.281, respectively. Time-to-tumor analysis by theWeibull model indicated beta-estimates of .016, 3.324, and 5.825 for dietary fat, carbohydrate, and fiber, respectively, indicating that fat shortens and fiber increases the length of time to tumor . The statistical model derived from these results also indicates a significant synergistic interaction of dietary fat and carbohydrate on final body weight and tumor incidence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:37:23