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Titolo:
ANGIOTENSIN-II AND ENDOTHELIN-1 RECEPTOR ANTAGONISTS HAVE CUMULATIVE HYPOTENSIVE EFFECTS IN CANINE PAGE HYPERTENSION
Autore:
MASSART PE; HODEIGE DG; VANMECHELEN H; CHARLIER AA; KETELSLEGERS JM; HEYNDRICKX GR; DONCKIER JE;
Indirizzi:
UNIV LOUVAIN,FONDS NATL RECH SCI,DEPT PHYSIOL,AVE HIPPOCRATE 55-5560 B-1200 BRUSSELS BELGIUM UNIV LOUVAIN,DEPT CARDIOL B-1200 BRUSSELS BELGIUM UNIV LOUVAIN,UNIT DIABETOL & NUTR B-1200 BRUSSELS BELGIUM CTR CARDIOVASC AALST BELGIUM UCL MT GODINNE,UNIV HOSP,DIV ENDOCRINOL YVOIR BELGIUM UCL MT GODINNE,UNIV HOSP,DIV INTERNAL MED YVOIR BELGIUM
Titolo Testata:
Journal of hypertension
fascicolo: 6, volume: 16, anno: 1998,
pagine: 835 - 841
SICI:
0263-6352(1998)16:6<835:AAERAH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEART-FAILURE; VASCULAR HYPERTROPHY; IN-VIVO; CELLS; DOGS; RATS; SECRETION; EXPRESSION; IRL-1620;
Keywords:
PAGE HYPERTENSION; DOGS; ENDOTHELIN-1; ENDOTHELIN RECEPTOR ANTAGONIST; ANGIOTENSIN II RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P.E. Massart et al., "ANGIOTENSIN-II AND ENDOTHELIN-1 RECEPTOR ANTAGONISTS HAVE CUMULATIVE HYPOTENSIVE EFFECTS IN CANINE PAGE HYPERTENSION", Journal of hypertension, 16(6), 1998, pp. 835-841

Abstract

Objective To evaluate whether the cumulative hypotensive effect of the endothelin-1 receptor antagonist bosentan, previously demonstrated in the presence of an angiotensin converting enzyme inhibitor, persistsunder angiotensin II receptor blockade with losartan, Design The model of hypertension was canine renovascular hypertension (Page hypertension). Methods Ten conscious dogs, studied on two occasions, were administered losartan (a 0.1 mg/kg bolus plus 90 min infusion at 0.1 mg/kg per min) and then bosentan vehicle (experiment I) or losartan and thentwo cumulative doses of bosentan (a 0.3 mg/kg bolus plus 30 min infusion at 0.7 mg/kg per min; and a 3 mg/kg bolus plus 30 min infusion at 7 mg/kg per min; experiment II). Results At the end of the study, meanaortic pressure in dogs had decreased by 14% in experiment I (from 139 +/- 4.7 to 119 +/- 4.7 mmHg, P< 0.05), whereas a 28% reduction occurred in experiment II (from 145 +/- 8.9 to 104 +/- 5.0 mmHg, P< 0.005),corresponding to an additional 14% decrease after administration of bosentan (P< 0.005 between groups). This cumulative effect of bosentan was related to a decrease in systemic vascular resistance (from 1220 +/- 119 to 847 +/- 189 mmHg/ml per min per kg . 10(3), P< 0.05), Plasmaangiotensin II level increased similarly in both experiments (in experiment I from 133 +/- 43 to 622 +/- 145 pg/ml, P = 0.01; in experimentII from 198 +/- 63 to 771 +/- 134 pg/ml, P < 0.005) whereas plasma endothelin-1 level increased only in experiment II (from 3.8 +/- 0.4 to 32.7 +/- 3.2 pg/ml, P< 0.001). Conclusion The cumulative hypotensive effect of bosentan suggests that, besides angiotensin II, endothelin-1 is independently involved in the pathophysiology of hypertension, which presents new therapeutic perspectives. (C) 1998 Lippincott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:02:27