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Titolo:
REPRODUCIBILITY AND CLINICAL-VALUE OF NOCTURNAL HYPOTENSION - PROSPECTIVE EVIDENCE FROM THE SAMPLE STUDY
Autore:
OMBONI S; PARATI G; PALATINI P; VANASIA A; MUIESAN ML; CUSPIDI C; MANCIA G;
Indirizzi:
UNIV MILAN,OSPED SAN GERARDO DEI TINTORI,CATTEDRA MED INTERNA,VIA DONIZETTI 106 I-20052 MILAN ITALY OSPED SAN LUCA,IRCCS,IST AUXOL ITALIANO MILAN ITALY UNIV PADUA,CATTEDRA MED INTERNA PADUA ITALY UNIV BRESCIA,CATTEDRA SEMEIOT & METODOL MED BRESCIA ITALY OSPED MAGGIORE,CTR FISIOL CLIN & IPERTENS,IRCCS I-20122 MILAN ITALY OSPED SAN GERARDO,MED CLIN MONZA ITALY UNIV MILAN MILAN ITALY
Titolo Testata:
Journal of hypertension
fascicolo: 6, volume: 16, anno: 1998,
pagine: 733 - 738
SICI:
0263-6352(1998)16:6<733:RACONH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMBULATORY BLOOD-PRESSURE; LEFT-VENTRICULAR MASS; ESSENTIAL-HYPERTENSION;
Keywords:
AMBULATORY BLOOD PRESSURE MONITORING; DAY-NIGHT BLOOD PRESSURE CHANGES; DIPPERS; NON-DIPPERS; LEFT VENTRICULAR HYPERTROPHY; LISINOPRIL; HYDROCHLOROTHIAZIDE; ANTIHYPERTENSIVE TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Omboni et al., "REPRODUCIBILITY AND CLINICAL-VALUE OF NOCTURNAL HYPOTENSION - PROSPECTIVE EVIDENCE FROM THE SAMPLE STUDY", Journal of hypertension, 16(6), 1998, pp. 733-738

Abstract

Objective To assess whether modifications in the nighttime blood pressure fall caused by antihypertensive treatment predict the regression of end-organ damage of hypertension. Methods The analysis was performed in patients with essential hypertension and echocardiographically detected left ventricular hypertrophy involved in the SAMPLE study. For each patient, ambulatory blood pressure monitoring and echocardiographic determination of left ventricular mass index were performed at the end of a 4-week wash-out pretreatment period, after 3 and 12 months oftreatment with lisinopril or with lisinopril plus hydrochlorothiazideand after a final 4-week placebo period. For each ambulatory blood pressure monitoring the 24 h average, daytime average (0600-2400 h), night-time average (2400-0600 h) and day-night difference was computed. The percentages of dipper and non-dipper patients (i.e. the patients with night blood pressure falls greater and less than 10% of the daytimeaverage, respectively) were also computed. Results The reproducibility of the day-night difference was low, both for comparison of the pretreatment and final placebo periods (n =170) and for comparison of the third and the 12th month of treatment (n = 180). The reproducibility of the dipper-non-dipper dichotomy was also row, 35-40% of patients becoming non-dippers if they were dippers and vice versa, both with and without treatment The changes in left ventricular mass index after 12 months of treatment were significantly (P < 0.01) related to the changes in 24 h, daytime and night-time blood pressure (r always > 0.33), but this was not the case for the treatment-induced modification of the day-night difference (r = -0.03 and -0.008 for systolic and diastolic blood pressures, respectively). Conclusions Our results show that day-night blood pressure changes and the classification of patients into dippers and non-dippers are poorly reproducible over time. It also provides the first prospective evidence that treatment-induced changes in day-night blood pressure difference are not related to treatment-induced regression of left ventricular mass index, thus having a limited clinical significance. (C) 1998 Lippincott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:49:45