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Titolo:
METHYLPHENIDATE DECREASES REGIONAL CEREBRAL BLOOD-FLOW IN NORMAL HUMAN-SUBJECTS
Autore:
WANG GJ; VOLKOW ND; FOWLER JS; FERRIERI R; SCHLYER DJ; ALEXOFF D; PAPPAS N; LIEBERMAN J; KING P; WARNER D; WONG C; HITZEMANN RJ; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT RADIOL STONY BROOK NY 11794 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 HILLSIDE HOSP,DEPT PSYCHIAT GLEN OAKS NY 11004
Titolo Testata:
Life sciences
fascicolo: 9, volume: 54, anno: 1994,
pagine: 143 - 146
SICI:
0024-3205(1994)54:9<143:MDRCBI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE; METABOLISM; BRAIN;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Wang et al., "METHYLPHENIDATE DECREASES REGIONAL CEREBRAL BLOOD-FLOW IN NORMAL HUMAN-SUBJECTS", Life sciences, 54(9), 1994, pp. 143-146

Abstract

To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using O-15-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25+/-11%) and at 30 minutes (20+/-10%) after its administration. Decrements in CBF were homogeneousthrougout the brain (regional decrements 23-30%) and probably reflectthe vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:26:25