Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INVOLVEMENT OF DISTINCT PIONEER NEURONS IN THE FORMATION OF LAYER-SPECIFIC CONNECTIONS IN THE HIPPOCAMPUS
Autore:
SUPER H; MARTINEZ A; DELRIO JA; SORIANO E;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT ANIM & PLANT CELL BIOL,DIAGONAL 645 BARCELONA 08028 SPAIN UNIV BARCELONA,FAC BIOL,DEPT ANIM & PLANT CELL BIOL BARCELONA 08028 SPAIN
Titolo Testata:
The Journal of neuroscience
fascicolo: 12, volume: 18, anno: 1998,
pagine: 4616 - 4626
SICI:
0270-6474(1998)18:12<4616:IODPNI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTNATAL MURINE HIPPOCAMPUS; RECEPTOR TYROSINE KINASES; OCULAR DOMINANCE; SUBPLATE NEURONS; AXON GUIDANCE; RHESUS-MONKEY; MAMMALIAN NEOCORTEX; COLORECTAL-CANCER; CORTICAL-NEURONS; NERVOUS-SYSTEM;
Keywords:
CAJAL-RETZIUS CELLS; PIONEER NEURONS; SYNAPSE FORMATION; AXONAL GUIDANCE; ANTEROGRADE TRACERS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
H. Super et al., "INVOLVEMENT OF DISTINCT PIONEER NEURONS IN THE FORMATION OF LAYER-SPECIFIC CONNECTIONS IN THE HIPPOCAMPUS", The Journal of neuroscience, 18(12), 1998, pp. 4616-4626

Abstract

During neural development, specific recognition molecules provide thecues necessary for the formation of initial projection maps, which are reshaped later in development. In some systems, guiding cues for axonal pathfinding and target selection are provided by specific cells that are present only at critical times. For instance, the floor plate guides commissural axons in the spinal cord, and the subplate is involved in the formation of thalamocortical connections. Here we study the development of entorhinal and commissural connections to the murine hippocampus, which in the adult terminate in nonoverlapping layers. We show that two groups of pioneer neurons, Cajal-Retzius cells and GABAergic neurons, form layer-specific scaffolds that overlap with distinct hippocampal afferents at embryonic and early postnatal stages. Furthermore, at postnatal day 0 (P0)-P5, before the dendrites of pyramidal neurons develop, these pioneer neurons are preferential synaptic targetsfor hippocampal afferents. Birthdating analysis using 5'-bromodeoxyuridine (BrdU) pulses showed that most such early-generated neurons disappear at late postnatal stages, most likely by cell death. Together with previous studies, these findings indicate that distinct pioneer neurons are involved in the guidance and targeting of different hippocampal afferents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:45:43