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Titolo:
PREICTAL SPECT IN TEMPORAL-LOBE EPILEPSY - REGIONAL CEREBRAL BLOOD-FLOW IS INCREASED PRIOR TO ELECTROENCEPHALOGRAPHY-SEIZURE ONSET
Autore:
BAUMGARTNER C; SERIES W; LEUTMEZER F; PATARAIA E; AULL S; CZECH T; PIETRZYK U; RELIC A; PODREKA I;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,NEUROCHIRURG KLIN A-1090 VIENNA AUSTRIA KRANKENANSTALT RUDOLFSTIFTUNG WIEN,NEUROL ABT VIENNA AUSTRIA MAX PLANCK INST NEUROL RES D-50931 COLOGNE GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 6, volume: 39, anno: 1998,
pagine: 978 - 982
SICI:
0161-5505(1998)39:6<978:PSITE->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; ICTAL SPECT; LOCALIZATION; FOCI; PET; PATTERNS; MRI; CT;
Keywords:
TEMPORAL LOBE EPILEPSY; SPECT; EPILEPSY SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C. Baumgartner et al., "PREICTAL SPECT IN TEMPORAL-LOBE EPILEPSY - REGIONAL CEREBRAL BLOOD-FLOW IS INCREASED PRIOR TO ELECTROENCEPHALOGRAPHY-SEIZURE ONSET", The Journal of nuclear medicine, 39(6), 1998, pp. 978-982

Abstract

Peri-ictal SPECT provides unique information on the dynamic changes in regional cerebral blood flow (rCBF) that occur during seizure evolution and, thus, could be useful in clarifying the poorly understood interplay of the interictal and ictal states in human focal epilepsy. Theregional hyperperfusion observed on ictal SPECT is generally believedto be a consequence of electrical seizure activity. However, recent studies using invasive long-term cortical CBF monitoring have demonstrated that rCBF changes occur up to 20 min prior to ictal electroencephalography (EEG) onset. Because of apparent technical difficulties, no preictal SPECT studies have been reported so far. Therefore, we presentour results on two patients with temporal lobe epilepsy in whom preictal SPECT scans were performed fortuitously under continuous video-BEGmonitoring control. Methods: Technetium-99m-hexamethyl propyleneamineoxime was injected 11 min (Patient 1) and 12 min (Patient 2) before clinical and EEG seizure onset, as documented from simultaneous video-EEG monitoring in two patients with temporal lobe epilepsy. We obtainedaccurate anatomical reference of CBF changes visible on SPECT by a special coregistration technique of MRI and SPECT. Results: Whereas interictal SPECT showed a hypoperfusion of the temporal lobe ipsilateral to the seizure focus, on preictal SPECT, a significant increase in rCBFin the epileptic temporal lobe could be observed. These rCBF changes were not accompanied by any significant changes of the ongoing EEG. Conclusion: Our study provides evidence that rCBF is increased in the epileptic temporal lobe several minutes before EEG seizure onset. Thus, rCBF changes observed on peri-ictal SPECT scan cannot be considered a mere consequence of EEG seizure activity but may rather reflect a change in neuronal activity precipitating the transition from the interictal to the ictal state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:04:47