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Titolo:
CONTRIBUTION OF CD14 TO ENDOTOXIN-INDUCED LIVER-INJURY MAY DEPEND ON TYPES OF MACROPHAGE ACTIVATION IN RATS
Autore:
TOSHIMA K; MOCHIDA S; ISHIKAWA K; MATSUI A; ARAI M; OGATA I; FUJIWARA K;
Indirizzi:
SAITAMA MED SCH,DEPT INTERNAL MED 3,38 MOROHONGO MOROYAMA SAITAMA 35004 JAPAN SAITAMA MED SCH,DEPT INTERNAL MED 3 MOROYAMA SAITAMA 35004 JAPAN UNIV TOKYO,DEPT INTERNAL MED 1,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 246, anno: 1998,
pagine: 731 - 735
SICI:
0006-291X(1998)246:3<731:COCTEL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASSIVE HEPATIC-NECROSIS; PARTIAL-HEPATECTOMY; CELLS; CLONING; PATHOGENESIS; COAGULATION; ADHESION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Toshima et al., "CONTRIBUTION OF CD14 TO ENDOTOXIN-INDUCED LIVER-INJURY MAY DEPEND ON TYPES OF MACROPHAGE ACTIVATION IN RATS", Biochemical and biophysical research communications, 246(3), 1998, pp. 731-735

Abstract

Activated Kupffer cells and hepatic macrophages can produce massive liver necrosis through microcirculatory disturbance due to sinusoidal fibrin deposition. This mechanism is involved in the development of liver injury after endotoxin administration in rats pretreated with heat-killed Propionibacterium acnes (P.acnes) or undergoing 70% liver resection. The significance of CD14, a receptor for lipopolysaccharide and its binding protein, was evaluated in both models in relation to the activation mechanisms of Kupffer cells and hepatic macrophages. Northern blot analysis revealed that CD14 mRNA expression was increased in the liver of rats following P.acnes administration. In these rats, hepatic macrophages immediately after isolation showed marked increase of CD14 mRNA expression compared to Kupffer cells from normal rats. In contrast, CD14 mRNA expression was minimal in partially resected liver. Interleukin (IL)-18 and IL-2 mRNA expression in the liver and interferon (IFN)-gamma mRNA expression in the spleen were significantly increased in P.acnes-treated rats compared to normal rats, while these increases were absent in partially hepatectomized rats. Thus, CD14 expressedon hepatic macrophages after activation through a cytokine network ofIL-18, IFN-gamma, and IL-2 may contribute to endotoxin-induced liver injury in P.acnes-treated rats. In contrast, in partially hepatectomized rats, this network may not operate during Kupffer cell activation, and the liver injury might develop through endotoxin receptors other than CD14 on the cells. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:55:28